HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Intrahepatic Cholestasis of Pregnancy

A reversible form of cholestasis that typically occurs in the third trimester of pregnancy and frequently recurs in subsequent pregnancies. Patients present with PRURITIS; JAUNDICE increased serum bile salts, and abnormal liver enzyme levels. Symptoms resolve soon after delivery; some patients with may also be susceptible to oral contraceptive-induced cholestasis. Fetal complications may occur, including PLACENTAL INSUFFICIENCY; PREMATURE LABOR; FETAL DISTRESS, and intrauterine death . A heterozygous mutation in the ATP8B1 gene has been identified. OMIM: 147480
Also Known As:
Cholestasis, Intrahepatic, Of Pregnancy; Cholestasis, Pregnancy-Related; Cholestasis, intrahepatic of pregnancy; Familial intrahepatic cholestasis of pregnancy; Familial recurrent intrahepatic cholestasis of pregnancy; Obstetric Cholestasis; Pregnancy related cholestasis; Pregnancy-Related Cholestasis; Recurrent intrahepatic cholestasis of pregnancy
Networked: 730 relevant articles (34 outcomes, 102 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Pruritus (Itching)
2. Cholestasis
3. Liver Diseases (Liver Disease)
4. Sclerosing Cholangitis
5. Fetal Death

Experts

1. Williamson, Catherine: 48 articles (01/2022 - 08/2002)
2. Marschall, Hanns-Ulrich: 22 articles (11/2021 - 08/2004)
3. Chambers, Jenny: 19 articles (01/2021 - 11/2003)
4. Shao, Yong: 17 articles (07/2022 - 12/2007)
5. Beuers, Ulrich: 13 articles (12/2020 - 02/2004)
6. Dixon, Peter H: 11 articles (01/2021 - 08/2007)
7. Ovadia, Caroline: 10 articles (11/2021 - 07/2013)
8. Williamson, C: 10 articles (09/2021 - 04/2001)
9. Geenes, Victoria: 10 articles (01/2021 - 05/2009)
10. Ding, Min: 9 articles (01/2022 - 12/2007)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Intrahepatic Cholestasis of Pregnancy:
1. Ursodeoxycholic Acid (Urso)FDA LinkGeneric
2. Bile Acids and Salts (Bile Acids)IBA
3. S-Adenosylmethionine (Ademetionine)IBA
4. Dexamethasone (Maxidex)FDA LinkGeneric
5. guar gum (guaran)IBA
6. Rifampin (Rifampicin)FDA LinkGeneric
7. Cholestyramine Resin (Questran)FDA LinkGeneric
8. Biomarkers (Surrogate Marker)IBA
9. Estrogens (Estrogen)FDA Link
10. MagnesiumIBA

Therapies and Procedures

1. Therapeutics
2. Plasma Exchange
3. Total Parenteral Nutrition
4. Intravenous Administration
5. Cesarean Section (Caesarean Section)