familial Joint laxity

An autosomal dominant disorder formerly classified as a type of EHLERS-DANLOS SYNDROME and characterized by joint laxity, recurrent joint dislocation, congenital hip dislocation, and patella dislocation. OMIM: 147900

Also Known As:

Joint laxity, familial; Articular hypermobility syndrome; Familial joint instability syndrome; Joint instability syndrome

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Disease Context: Research Results

Musculoskeletal Diseases: 719
- Joint Diseases: 6509
  - Joint Instability: 584
    - familial Joint laxity: 2

Related Diseases

1.	Type IV Ehlers-Danlos Syndrome
2.	Ehlers-Danlos syndrome type 3

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to familial Joint laxity:

1.	Collagen Type III (Type III Collagen)IBA 09/01/1994 - "Thus mutations of type III collagen can cause either EDS IV or EDS III. Two affected family members had virtually normal skin and so more closely resembled the phenotype of articular hypermobility syndrome." 09/01/1994 - "A family with Ehlers-Danlos syndrome type III/articular hypermobility syndrome has a glycine 637 to serine substitution in type III collagen."
2.	Serine (L-Serine)FDA Link 09/01/1994 - "A family with Ehlers-Danlos syndrome type III/articular hypermobility syndrome has a glycine 637 to serine substitution in type III collagen."
3.	Progesterone FDA LinkGeneric 08/01/1992 - "The somatic changes involve general laxity of the articular ligaments, attributable to either the physiologic effects of progesterone or a genetic trait consisting of familial joint laxity. "
4.	Glycine (Aminoacetic Acid)FDA LinkGeneric 09/01/1994 - "A family with Ehlers-Danlos syndrome type III/articular hypermobility syndrome has a glycine 637 to serine substitution in type III collagen."