Pulmonary edema of mountaineers

An elevated mean pulmonary artery pressure that occurs in populations who live at or above 2000 m above sea level. Polymorphisms in the GUCY1A3 gene may confer protection. OMIM: 178400

Also Known As:

Networked: 26 relevant articles (1 outcomes, 2 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Altitude Sickness (Mountain Sickness)
2.	Vascular Remodeling
3.	Hypoxia (Hypoxemia)
4.	Right Ventricular Hypertrophy

Experts

1.	Hannemann, Juliane: 3 articles (12/2021 - 01/2018)
2.	Bailey, Damian M: 3 articles (03/2011 - 01/2009)
3.	Berger, Marc M: 3 articles (03/2011 - 01/2009)
4.	Bärtsch, Peter: 3 articles (03/2011 - 01/2009)
5.	Dehnert, Christoph: 3 articles (03/2011 - 01/2009)
6.	Luks, Andrew M: 3 articles (03/2011 - 01/2009)
7.	Mairbäurl, Heimo: 3 articles (03/2011 - 01/2009)
8.	Menold, Elmar: 3 articles (03/2011 - 01/2009)
9.	Swenson, Erik R: 3 articles (03/2011 - 01/2009)
10.	Brito, Julio: 2 articles (12/2021 - 01/2018)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Pulmonary edema of mountaineers:

1.	TanninsIBA 05/06/2023 - "Protective effects of the Terminalia bellirica tannin-induced Nrf2/HO-1 signaling pathway in rats with high-altitude pulmonary hypertension."
2.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 04/25/2011 - "The aim of this study was to investigate the effect of integripetal rhodiola herb on pulmonary arterial remodeling and expression of vascular endothelial growth factor (VEGF) in high altitude pulmonary hypertension in rats. "
3.	Dexamethasone (Maxidex)FDA LinkGeneric 01/01/2022 - "Thus, for the first time, this study shows a sex-biased regulation by dexamethasone of physiologic parameters resulting from the hypoxic environment of high-altitude, which impacts the development of high-altitude pulmonary hypertension and acute mountain sickness. "
4.	Nitric Oxide (Nitrogen Monoxide)FDA Link 01/01/2018 - "High-altitude pulmonary hypertension (HAPH) is a life-threating condition for animals in high altitude, and disturbance of endothelial nitric oxide (NO) synthesis contributes to its pathogenesis. " 12/01/2010 - "High-altitude pulmonary hypertension is associated with a free radical-mediated reduction in pulmonary nitric oxide bioavailability." 12/09/2021 - "Chronic intermittent hypoxia leads to high-altitude pulmonary hypertension, which is associated with high asymmetric dimethylarginine (ADMA), an endogenous inhibitor of nitric oxide synthesis. "
5.	Oxygen (Dioxygen)IBA 01/01/2023 - "24:1-6, 2023.-Chronic high-altitude exposure reduces oxygen delivery to the fetus during pregnancy and causes pathologic pulmonary artery remodeling, This increases the risk of high-altitude pulmonary hypertension (PH), which is a particularly fatal disease that is difficult to treat. " 09/01/2021 - "Markers of cardiovascular risk and their reversibility with acute oxygen therapy in Kyrgyz highlanders with high altitude pulmonary hypertension."
6.	Atrial Natriuretic Factor (ANF)IBA 03/01/2020 - "We aimed to assess changes of ANF in chronic mountain disease by measuring HRV in patients with high altitude pulmonary hypertension (HAPH). " 09/01/1995 - "Since the renin-angiotensin-aldosterone system and atrial natriuretic factor are directly involved in the regulation of hemodynamics and structural alterations in the circulatory system, the interest of investigators in the observed changes in this system during exogenous hypoxia and the resultant development of high-altitude pulmonary hypertension is quite understandable. " 09/01/1995 - "Atrial natriuretic factor in high-altitude pulmonary hypertension: the influence of acute hypoxia on plasma atrial natriuretic factor, renin, and aldosterone concentrations in highlanders with initially normal or elevated pulmonary artery pressure and without evidence of right ventricular hypertrophy."
7.	N,N-dimethylarginine (asymmetric dimethylarginine)IBA 04/01/2020 - "We have recently shown that high asymmetric dimethylarginine at sea level is a predictor for high-altitude pulmonary hypertension. " 12/09/2021 - "Chronic intermittent hypoxia leads to high-altitude pulmonary hypertension, which is associated with high asymmetric dimethylarginine (ADMA), an endogenous inhibitor of nitric oxide synthesis. "
8.	Endothelin Receptor AntagonistsIBA 03/01/2009 - "To date, no evidence has confirmed whether endothelin-receptor antagonists have efficacy in the treatment of high-altitude pulmonary hypertension."
9.	Phosphodiesterase 5 InhibitorsIBA 01/01/2010 - "Phosphodiesterase type 5 inhibitors for high-altitude pulmonary hypertension: a meta-analysis."
10.	Type 5 Cyclic Nucleotide PhosphodiesterasesIBA 08/01/2005 - "Phosphodiesterase type 5 and high altitude pulmonary hypertension."

Therapies and Procedures

1.	Therapeutics 10/01/2021 - "However, no drugs have been approved to date for the therapy of chronic high altitude pulmonary hypertension. " 09/01/2021 - "Markers of cardiovascular risk and their reversibility with acute oxygen therapy in Kyrgyz highlanders with high altitude pulmonary hypertension."