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severe chronic Neutropenia

A hereditary form of chronic neutropenia that may be autosomal dominant or recessive. Affected individuals may also present with CLUBBED FINGERS; PERIODNTITIS, hyperplastic GINGIVITIS, recurrent oral ulcerations, and tooth loss. OMIM: 162700
Also Known As:
Neutropenia, severe chronic; Leukopenia, benign familial; Neutropenia, chronic familial
Networked: 63 relevant articles (9 outcomes, 8 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Neutropenia
2. Infections
3. Autosomal Recessive 3 Severe Congenital Neutropenia
4. Acquired Immunodeficiency Syndrome (AIDS)
5. Aplastic Anemia (Anemia, Hypoplastic)

Experts

1. Dale, David C: 12 articles (12/2022 - 06/2006)
2. Welte, Karl: 8 articles (01/2019 - 04/2002)
3. Zeidler, Cornelia: 7 articles (01/2019 - 04/2002)
4. Newburger, Peter E: 6 articles (12/2022 - 01/2006)
5. Alter, Blanche P: 6 articles (07/2010 - 04/2002)
6. Bolyard, Audrey Anna: 5 articles (12/2022 - 07/2006)
7. Boxer, Laurence A: 5 articles (01/2019 - 06/2006)
8. Donadieu, Jean: 4 articles (01/2021 - 04/2002)
9. Welte, K: 4 articles (12/2001 - 02/2000)
10. Bonilla, Mary Ann: 3 articles (12/2022 - 06/2006)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to severe chronic Neutropenia:
1. LenograstimIBA
2. Granulocyte Colony-Stimulating Factor (G-CSF)IBA
3. Filgrastim (Neupogen)FDA Link
4. Antiviral Agents (Antivirals)IBA
5. Anti-Bacterial Agents (Antibiotics)IBA
6. sargramostim (Leukine)FDA Link
7. Zidovudine (Retrovir)FDA LinkGeneric
8. Antineoplastic Agents (Antineoplastics)IBA
9. molgramostimIBA
10. Leukocyte Elastase (Neutrophil Elastase)IBA

Therapies and Procedures

1. Therapeutics
2. Bone Marrow Transplantation (Transplantation, Bone Marrow)
3. Drug Therapy (Chemotherapy)
06/01/1996 - "In clinical practice they have beneficial effects on the neutropenia following cytotoxic chemotherapy, bone marrow transplantation, and it may be effective in severe chronic neutropenia by cause drugs. "
02/01/1994 - "Rapidly accumulating evidence appears to justify the use of CSFs for the prevention of fever and infections in several clinical settings, such as chemotherapy-associated neutropenia, bone marrow transplantation, and severe chronic neutropenia. "
05/01/1997 - "Through Medline searches and personal files, we have reviewed the published literature on the efficacy and cost of GM-CSF and G-CSF in patients with severe chronic neutropenia and those receiving standard dose chemotherapy or high-dose chemotherapy requiring bone marrow reconstitution. "
05/01/1997 - "Recommendations for the use of G-CSF and/or GM-CSF include: (1) the prevention of recurrent, debilitating infections in patients with severe chronic neutropenia; and (2) the maintaining of dose-intensity of potentially curative, standard-dose chemotherapy. "
04/01/2016 - "Tbo-filgrastim (filgrastim XM02; Biograstim(®), Ratiograstim(®), Tevagrastim(®)) is approved in the EU as a biosimilar of filgrastim (Neupogen(®)) for use in all indications for which reference filgrastim is approved, including chemotherapy-induced neutropenia, neutropenia in patients undergoing myeloablative therapy followed by bone marrow transplantation, mobilization of peripheral blood stem cells (PBSCs), severe chronic neutropenia, and neutropenia in HIV infection. "
4. Stem Cell Transplantation
5. Hematopoietic Stem Cell Mobilization