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Accutane embryopathy
Also Known As:
Accutane-exposed pregnancies; Isotretinoin (RoAccutane) embryopathy; Isotretinoin embryopathy
Networked:
2
relevant articles (
0
outcomes,
0
trials/studies)
Disease Context: Research Results
Congenital, Hereditary, and Neonatal Diseases and Abnormalities: 933
Congenital Abnormalities: 25723
Drug-Induced Abnormalities: 11
Accutane embryopathy: 2
Organic Chemicals: 133
Hydrocarbons: 1713
Terpenes: 1461
Carotenoids: 4095
Retinoids: 5957
Isotretinoin: 3069
Accutane embryopathy: 2
Cyclic Hydrocarbons: 97
Alicyclic Hydrocarbons: 1
Cycloparaffins: 6
Cyclohexanes: 3
Cyclohexenes: 4
Carotenoids: 4095
Retinoids: 5957
Isotretinoin: 3069
Accutane embryopathy: 2
Acyclic Hydrocarbons
Alkenes: 265
Polyenes: 164
Carotenoids: 4095
Retinoids: 5957
Isotretinoin: 3069
Accutane embryopathy: 2
Biological Factors: 2472
Biological Pigments: 1
Carotenoids: 4095
Retinoids: 5957
Isotretinoin: 3069
Accutane embryopathy: 2
Drugs and Biologics
Drugs and Important Biological Agents (IBA) related to Accutane embryopathy:
1.
Isotretinoin (Accutane)
FDA Link
Generic
05/01/1989 - "
We here describe these five cases of isotretinoin embryopathy, including available information on the circumstances which led to maternal use of isotretinoin during the first trimester of pregnancy.
"
01/01/1986 - "
Since during normal repetitive dosing in the human the mean trough blood concentration of isotretinoin ranges from 132 to 196 ng/ml, while 4-oxo-isotretinoin ranges from 610 to 791 ng/ml, it is likely that the metabolite plays a major role in the induction of the isotretinoin embryopathy.
"
2.
4-oxoretinoic acid
IBA
01/01/1986 - "
Since during normal repetitive dosing in the human the mean trough blood concentration of isotretinoin ranges from 132 to 196 ng/ml, while 4-oxo-isotretinoin ranges from 610 to 791 ng/ml, it is likely that the metabolite plays a major role in the induction of the isotretinoin embryopathy.
"