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Accutane embryopathy

Also Known As:

Accutane-exposed pregnancies; Isotretinoin (RoAccutane) embryopathy; Isotretinoin embryopathy

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Disease Context: Research Results

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Accutane embryopathy:

1.	Isotretinoin (Accutane)FDA LinkGeneric 05/01/1989 - "We here describe these five cases of isotretinoin embryopathy, including available information on the circumstances which led to maternal use of isotretinoin during the first trimester of pregnancy. " 01/01/1986 - "Since during normal repetitive dosing in the human the mean trough blood concentration of isotretinoin ranges from 132 to 196 ng/ml, while 4-oxo-isotretinoin ranges from 610 to 791 ng/ml, it is likely that the metabolite plays a major role in the induction of the isotretinoin embryopathy."
2.	4-oxoretinoic acidIBA 01/01/1986 - "Since during normal repetitive dosing in the human the mean trough blood concentration of isotretinoin ranges from 132 to 196 ng/ml, while 4-oxo-isotretinoin ranges from 610 to 791 ng/ml, it is likely that the metabolite plays a major role in the induction of the isotretinoin embryopathy."