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Episodic ataxia with nystagmus

Also Known As:
Acetazolamide-responsive episodic ataxia syndrome; Acetazolamide-responsive, hereditary, paroxysmal, cerebellar ataxia; Ataxia, familial, paroxysmal; Cerebellar ataxia, paroxysmal, Acetazolamide-responsive; Cerebellopathy, hereditary paroxysmal; Episodic ataxia type 2; Nystagmus-associated episodic ataxia
Networked: 129 relevant articles (4 outcomes, 3 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Strupp, Michael: 6 articles (07/2013 - 04/2007)
2. Brandt, Thomas: 5 articles (07/2013 - 04/2007)
3. Baloh, Robert W: 5 articles (01/2012 - 02/2002)
4. Jen, Joanna C: 4 articles (02/2008 - 04/2002)
5. Frontali, M: 4 articles (01/2003 - 01/2000)
6. Spacey, Sian D: 3 articles (01/2013 - 08/2004)
7. Tournier-Lasserve, E: 3 articles (05/2011 - 02/2001)
8. Kullmann, D M: 3 articles (11/2009 - 02/2001)
9. Baloh, R W: 3 articles (12/2003 - 10/2001)
10. Jodice, C: 3 articles (01/2003 - 01/2000)

Related Diseases

1. Migraine with Aura (Familial Hemiplegic Migraine)
2. Cerebellar Diseases (Cerebellar Syndrome)
3. Epilepsy (Aura)
09/08/2001 - "We aimed to determine whether the P/Q-type Ca(2+) channel is associated with both epilepsy and episodic ataxia type 2 in human beings. "
01/12/2002 - "Human epilepsy, episodic ataxia type 2, and migraine."
03/01/2003 - "Acetazolamide, which is thought to ameliorate ion channel function, was shown effective in familial hemiplegic migraine and episodic ataxia type 2, both of which are associated with mutations of the neuronal Ca2+-channel gene CACNA1A, as well as in aura status. "
12/01/2001 - "Here, we reviewed several channelopathies including spinocerebellar ataxia type 6, familial hemiplegic migraine, episodic ataxia type 2, familial hypokalemic periodic paralysis, congenital myotonia, malignant hyperthermia, epilepsy, Gitelman syndrome and Lambert-Eaton syndrome."
01/01/2001 - "(1) Sodium channelopathies: familial generalized epilepsy with febrile seizures plus, hyperkalemic periodic paralysis, paramyotonias, hypokalemic periodic paralysis; (2) potassium channelopathies: benign infantile epilepsy, episodic ataxia type 1; (3) calcium channelopathies: episodic ataxia type 2, spinocerebellar ataxia type 6, familial hemiplegic migraine, hypokalemic periodic paralysis, central core disease, malignant hyperthermia syndrome, congenital stationary night blindness; (4) chloride channelopathies: myotonia congenitas; (5) ACh receptor channelopathies: autosomal dominant frontal lobe nocturnal epilepsy, congenital myasthenic syndromes; (6) glycine receptor channelopathies: hyperekplexia. "
4. Vestibular Neuronitis (Vestibular Neuritis)
01/01/2013 - "Considerable advances have been made in the treatment of vertigo disorders in the last 10 years, e.g., cortisone for the treatment of acute vestibular neuritis, betahistine as a high-dosage, long-term treatment for Menière's disease, carbamazepine to treat vestibular paroxysmia and aminopyridine for downbeat nystagmus and episodic ataxia type 2."
07/01/2009 - "In vestibular neuritis, recovery of the peripheral vestibular function can be improved by oral corticosteroids; in Menière's disease, there is first evidence that high-dose, long-term administration of betahistine reduces attack frequency; carbamazepine or oxcarbamazepine is the treatment of first choice in vestibular paroxysmia, a disorder mainly caused by neurovascular cross-compression; the potassium channel blocker aminopyridine provides a new therapeutic principle for treatment of downbeat nystagmus, upbeat nystagmus, and episodic ataxia type 2."
03/01/2011 - "Examples of such causal therapy include aminopyridines for downbeat nystagmus and episodic ataxia type 2; carbamazepine for vestibular paroxysmia, paroxsymal dysarthria and ataxia in multiple sclerosis, and superior oblique myokymia; betahistine, dexamethasone, and gentamicin for Menière's disease; gabapentin and memantine for different forms of acquired and congenital nystagmus; corticosteroids for acute vestibular neuritis and Cogan's syndrome; metoprolol and topiramate for vestibular migraine; and selective serotonin reuptake inhibitors such as paroxetine for phobic postural vertigo. "
5. Low Vision (Subnormal Vision)

Related Drugs and Biologics

1. Acetazolamide (Diamox)
2. Potassium Channels (Potassium Channel)
3. 4-Aminopyridine (4 Aminopyridine)
4. Betahistine (Serc)
5. Adrenal Cortex Hormones (Corticosteroids)
6. Ion Channels (Ion Channel)
7. Carbamazepine (Tegretol)
8. gabapentin (Neurontin)
9. GABA-B Receptor Agonists
10. Voltage-Gated Potassium Channels (Voltage-Gated Potassium Channel)

Related Therapies and Procedures

1. Off-Label Use
2. Optical Devices
3. Contact Lenses
4. Microelectrodes
5. Drug Therapy (Chemotherapy)