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Holt-Oram syndrome

A genetic condition with autosomal dominant inheritance that is characterized by skeletal abnormalities of the upper limbs, particularly thumb and wrist anomalies; additional skeletal abnormalities may also be present. About 75% of those affected have heart abnormalities, notably ATRIAL SEPTAL DEFECTS and cardiac conduction defects. Mutations in the TBX5 gene have been identified. OMIM: 142900
Also Known As:
Atrio-Digital Syndrome; Atriodigital dysplasia; Cardiac-Limb Syndrome; Cervico-Oculo-Acoustic Syndrome; Heart-Hand Syndrome, Type 1; Heart-hand syndrome; Ventriculo-Radial Syndrome; Wildervanck syndrome
Networked: 82 relevant articles (1 outcomes, 3 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Congenital Heart Defects (Congenital Heart Defect)
2. Holt-Oram syndrome
3. Fetal Diseases (Embryopathy)
4. Ventricular Heart Septal Defects (Ventricular Septal Defect)
5. Duane Retraction Syndrome (Duane Syndrome)

Experts

1. Bruneau, Benoit G: 5 articles (12/2010 - 05/2004)
2. Brook, J David: 3 articles (11/2019 - 04/2003)
3. Mori, Alessandro D: 3 articles (12/2010 - 05/2004)
4. Seidman, J G: 3 articles (09/2006 - 09/2001)
5. Basson, C T: 3 articles (02/2001 - 01/2000)
6. Barnett, Phil: 2 articles (01/2022 - 12/2014)
7. Ghosh, Tushar K: 2 articles (11/2019 - 04/2005)
8. Arisi, Ivan: 2 articles (01/2016 - 12/2015)
9. Baumgart, Mario: 2 articles (01/2016 - 12/2015)
10. Chiavacci, Elena: 2 articles (01/2016 - 12/2015)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Holt-Oram syndrome:
1. Transcription Factors (Transcription Factor)IBA
2. Proteins (Proteins, Gene)FDA Link
3. Thalidomide (Thalomid)FDA Link
4. Anesthetics (Anesthetic Agents)IBA
5. T-box transcription factor 5IBA
6. MicroRNAs (MicroRNA)IBA
7. DNA (Deoxyribonucleic Acid)IBA
8. Coenzyme A (CoA)IBA
9. Brachyury protein (Brachyury)IBA
10. antineoplaston A10 (A 10)IBA

Therapies and Procedures

1. Cesarean Section (Caesarean Section)
2. Implantable Defibrillators (Implantable Cardioverter-Defibrillator)
3. Anesthesia
4. Hip Replacement Arthroplasty (Total Hip Replacement)
5. Therapeutics