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Chromosome 5q Deletion Syndrome

A MYELODYSPLASTIC SYNDROME that arises from a defect in erythroid differentiation. Patients present with severe macrocytic anemia, normal or elevated PLATELET counts, normal or reduced NEUTROPHIL counts, erythroid hypoplasia in the BONE MARROW, and hypolobated micromegakaryocytes. A somatic deletion of the RPS14 gene has been identified. OMIM: 153550
Also Known As:
5q deletion syndrome; 5q- syndrome; Macrocytic Anemia, Refractory, Due To 5q Deletion; Refractory macrocytic anemia due to 5q deletion
Networked: 85 relevant articles (7 outcomes, 6 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Anemia
2. Thrombocytosis (Thrombocythemia)
3. Myelodysplastic Syndromes (Myelodysplastic Syndrome)
4. Essential Thrombocythemia
5. Diamond-Blackfan Anemia (Anemia, Diamond Blackfan)

Experts

1. Boultwood, Jacqueline: 9 articles (07/2015 - 06/2004)
2. Pellagatti, Andrea: 9 articles (07/2015 - 06/2004)
3. Wainscoat, James S: 7 articles (01/2013 - 06/2004)
4. Ebert, Benjamin L: 6 articles (11/2014 - 01/2008)
5. Narla, Anupama: 4 articles (12/2016 - 04/2010)
6. List, Alan F: 4 articles (12/2013 - 05/2005)
7. Padron, Eric: 3 articles (12/2013 - 02/2011)
8. Boultwood, J: 3 articles (08/2013 - 05/2000)
9. Wainscoat, J S: 3 articles (08/2013 - 05/2000)
10. Fenaux, Pierre: 3 articles (07/2013 - 01/2006)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Chromosome 5q Deletion Syndrome:
1. Lenalidomide (CC 5013)FDA Link
2. Leucine (L-Leucine)FDA Link
3. DeferasiroxFDA Link
4. Thalidomide (Thalomid)FDA Link
5. SuspensionsIBA
6. Dexamethasone (Maxidex)FDA LinkGeneric
7. Ribosomal Proteins (Ribosomal Protein)IBA
8. MicroRNAs (MicroRNA)IBA
9. Fibroblast Growth Factor 2 (Basic Fibroblast Growth Factor)IBA
10. Transforming Growth Factor beta (TGF-beta)IBA

Therapies and Procedures

1. Therapeutics
2. Stem Cell Transplantation
3. Chelation Therapy (Therapy, Chelation)
4. Drug Therapy (Chemotherapy)
5. Blood Transfusion (Blood Transfusions)