|1.||Boultwood, Jacqueline: 12 articles (07/2015 - 06/2002)|
|2.||Wainscoat, James S: 10 articles (12/2013 - 06/2002)|
|3.||Pellagatti, Andrea: 9 articles (07/2015 - 07/2008)|
|4.||Ebert, Benjamin L: 7 articles (12/2013 - 01/2008)|
|5.||Giagounidis, Aristoteles: 4 articles (12/2013 - 12/2006)|
|6.||List, Alan F: 4 articles (12/2013 - 11/2007)|
|7.||Aul, Carlo: 4 articles (12/2013 - 12/2006)|
|8.||Narla, Anupama: 4 articles (10/2013 - 04/2010)|
|9.||Malcovati, Luca: 4 articles (07/2013 - 07/2008)|
|10.||Ellis, Steven R: 3 articles (03/2015 - 01/2008)|
12/01/2011 - "The 5q- syndrome is a myelodsyplastic syndrome (MDS) characterized by symptomatic anemia and an indolent natural history with low transformation potential. "
01/01/1984 - "The 5q- syndrome is a recently described entity characterized by partial deletion of the long arm of chromosome No. 5 and by hematologic findings of chronic anemia with reticulocytopenia, nonlobulated megakaryocytes, and megathrombocytes. "
03/01/2010 - "Anemia is a characteristic of myelodysplastic syndromes, such as the rare 5q- syndrome, but its mechanism remains unclear. "
01/01/2013 - "Recent studies have shown that l-leucine treatment of zebrafish and murine models of the 5q- syndrome and DBA results in a marked improvement in the anemia. "
07/01/2015 - "Haploinsufficiency of the ribosomal protein gene RPS14 plays a critical role in the development of anemia in the 5q- syndrome, and haploinsufficiency of CUX1 is important in some patients with MDS and AML with complete or partial loss of chromosome 7. Gene expression profiling has identified key deregulated genes and pathways and new prognostic gene signatures in MDS. "
|2.||Myelodysplastic Syndromes (Myelodysplastic Syndrome)
02/01/2011 - "With the emerging data elucidating the pathogenesis of the 5q- syndrome and the success of clinical trials, a cohesive story connecting the biology and pharmacology associated with this subtype of myelodysplastic syndromes has emerged."
11/01/2015 - "Van den Berghe's 5q- syndrome and myelodysplastic syndrome with isolated del(5q)."
01/01/2015 - "The 5q- syndrome is the most distinct of the myelodysplastic syndromes (MDS) and patients with this disorder have a deletion of chromosome 5q [del(5q)] as the sole karyotypic abnormality. "
12/01/2012 - "5q- syndrome is a newly defined subtype of myelodysplastic syndrome (MDS) first proposed by the World Health Organization in 2001. "
01/01/2012 - "In recent years we have gained great insight into the molecular pathogenesis of the 5q- syndrome, the most distinct of all the myelodysplastic syndromes. "
|3.||Chromosome Aberrations (Chromosome Abnormalities)
12/01/2010 - "A subset of patients with del(5q) as a sole cytogenetic abnormality has a consistent set of clinical features, termed the 5q- syndrome. "
12/01/2010 - "The biological characteristics of MDS in Korea seem to be markedly different from those of Caucasians, with Koreans having a younger age, lower frequencies of 5q- syndrome, higher frequencies of complex cytogenetic abnormalities including del(5q), and poorer prognosis. "
01/01/2009 - "With del(5q) as the sole cytogenetic abnormality, 5q- syndrome represents an opportunity to define precisely the molecular defect(s) underlying the pathogenesis of this disease. "
03/01/2003 - "We also suggest to define 5q- syndrome as primary MDS of FAB type RA with 5q deletion as a sole cytogenetic abnormality confirmed by FISH analysis. "
01/01/1995 - "Since cytogenetic abnormalities other than 5q- were also detected, she was considered to be type B of 5q- syndrome. "
|4.||Acute Myeloid Leukemia (Acute Myelogenous Leukemia)
05/01/2010 - "Two recently published studies using genetic approaches have unraveled a small array of genes whose alteration recapitulates critical features of the 5q- syndrome including dysplasia, clonal dominance, and progression to acute myeloid leukemia."
11/01/1993 - "Allelic loss of IRF1 in myelodysplasia and acute myeloid leukemia: retention of IRF1 on the 5q- chromosome in some patients with the 5q- syndrome."
06/01/1988 - "We report a case of 5q- syndrome that progressed to acute nonlymphocytic leukemia after 9 years of clinically and morphologically stable disease. "
06/01/1988 - "5q- syndrome terminating in acute myeloid leukemia. "
05/01/2010 - "Patients with 5q- syndrome are characterized by macrocytic anemia, normal to elevated platelet counts, and a propensity to develop acute myeloid leukemia. "
03/01/2010 - "EGR1 FISH detects del(5q) in a broad variety of myeloid neoplasms, including at least most cases of 5q- syndrome, while studies for CSF1R add little to the diagnostic yield."
08/01/2009 - "We performed a retrospective analysis of JAK2 V617F mutation in Chinese patients with myeloid neoplasms and isolated del(5q), and were able to demonstrate the frequent occurrence of JAK2 V617F mutation in 5q- syndrome."
08/01/2009 - "The cases included examples of isolated del(5q) chromosomal abnormality, including the "classical" 5q- syndrome and other myeloid neoplasms. "
|2.||lenalidomide (CC 5013)
|3.||Fibroblast Growth Factor 2 (Basic Fibroblast Growth Factor)
|4.||Transforming Growth Factor beta (TGF-beta)
|5.||Transforming Growth Factors (Transforming Growth Factor)
|6.||Platelet-Derived Growth Factor
|7.||Ribosomal Proteins (Ribosomal Protein)
|9.||Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF)
|1.||Chelation Therapy (Therapy, Chelation)
|2.||Blood Transfusion (Blood Transfusions)