|1.||Mulligan, Stephen P: 3 articles (12/2015 - 07/2012)|
|2.||Christopherson, Richard I: 3 articles (12/2015 - 07/2012)|
|3.||Best, O Giles: 3 articles (12/2015 - 07/2012)|
|4.||Kaufman, Kimberley L: 2 articles (12/2015 - 04/2013)|
|5.||Mactier, Swetlana: 2 articles (12/2015 - 04/2013)|
|6.||Che, Yiping: 2 articles (04/2013 - 07/2012)|
|7.||Alomari, Munther: 1 article (12/2015)|
|8.||Mirzaei, Mehdi: 1 article (12/2015)|
|9.||Haynes, Paul A: 1 article (12/2015)|
|10.||Jenkins, Yiping: 1 article (12/2015)|
|1.||B-Cell Chronic Lymphocytic Leukemia (Chronic Lymphocytic Leukemia)
04/05/2013 - "The proteomic effects of the Hsp90 inhibitor, SNX-7081, have been determined on the p53-mutated B-cell chronic lymphocytic leukemia (CLL) cell line, MEC1. "
12/01/2015 - "The Hsp90 inhibitor SNX-7081 is synergistic with fludarabine nucleoside via DNA damage and repair mechanisms in human, p53-negative chronic lymphocytic leukemia."
04/05/2013 - "Hsp90 Inhibitor SNX-7081 dysregulates proteins involved with DNA repair and replication and the cell cycle in human chronic lymphocytic leukemia (CLL) cells."
07/01/2012 - "The Hsp90 inhibitor SNX-7081 synergizes with and restores sensitivity to fludarabine in chronic lymphocytic leukemia cells with lesions in the TP53 pathway: a potential treatment strategy for fludarabine refractory disease."
12/01/2015 - "We previously showed that the Hsp90 inhibitor, SNX-7081, synergizes with and restores sensitivity to fludarabine nucleoside (2-FaraA) in human chronic lymphocytic leukemia (CLL) cells with lesions in the p53 pathway (Best OG, et al., Leukemia Lymphoma 53:1367-75, 2012). "
01/01/2015 - "The results showed that SNX-7081 exerted better inhibitory effects than SNX-2112 in six eighths of the human cancer cell lines, with an average IC50 of 1 µM. "
01/01/2015 - "Considering the superior effects against Hsp90 affinity, cell growth, apoptosis, and Hsp90 client proteins in a majority of human cancer cells, the novel SNX-7081 may be a promising alternative to SNX-2112, which merits further evaluation."
01/01/2015 - "Compared with SNX-2112, SNX-7081 exhibited more potent effects on cell apoptosis in four sixths of the human cancer cell lines, and was more active in the downregulation of Hsp90 client proteins. "
01/01/2015 - "Comparative effects of SNX-7081 and SNX-2112 on cell cycle, apoptosis and Hsp90 client proteins in human cancer cells."
|1.||Proteins (Proteins, Gene)
|3.||Protein Kinases (Protein Kinase)