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NVP 231

a ceramide kinase inhibitor; structure in first source

Also Known As:

NVP-231; NVP231

Networked: 4 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Bridged-Ring Compounds: 1
      - NVP 231: 4
Polycyclic Compounds: 6
- Bridged-Ring Compounds: 1
  - NVP 231: 4
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Thiazoles: 392
      - Benzothiazoles: 40
        NVP 231: 4
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzothiazoles: 40
      - NVP 231: 4

Experts

1.	Huwiler, Andrea: 2 articles (12/2014 - 01/2014)
2.	Pastukhov, Oleksandr: 2 articles (12/2014 - 01/2014)
3.	Pfeilschifter, Josef: 2 articles (12/2014 - 01/2014)
4.	Schwalm, Stephanie: 2 articles (12/2014 - 01/2014)
5.	Zangemeister-Wittke, Uwe: 2 articles (12/2014 - 01/2014)
6.	Fox, Todd: 1 article (02/2016)
7.	Gangoiti, Patricia: 1 article (02/2016)
8.	Gomez-Larrauri, Ana: 1 article (02/2016)
9.	Gomez-Muñoz, Antonio: 1 article (02/2016)
10.	Kester, Mark: 1 article (02/2016)

Related Diseases

1.	Pancreatic Neoplasms (Pancreatic Cancer) 02/15/2016 - "Pancreatic cancer cells engineered to overexpress ceramide kinase (CerK), the enzyme responsible for C1P biosynthesis in mammalian cells, showed enhanced spontaneous cell migration that was potently blocked by treatment with the selective CerK inhibitor NVP-231, or by treatment with specific CerK siRNA. "
2.	Ovarian Neoplasms (Ovarian Cancer) 01/01/2023 - "Proliferation and apoptosis assays were performed in ovarian cancer cells after CERK depletion, CERK overexpression, and NVP-231 treatment in the absence or presence of cisplatin. "
3.	Neoplasms (Cancer) 12/01/2014 - "Here, we studied the effect of a recently developed CerK inhibitor, NVP-231, on cancer cell proliferation and viability and investigated the role of cell cycle regulators implicated in these responses. " 12/01/2014 - "Our data demonstrate for the first time a crucial role for CerK in the M phase control in cancer cells and suggest its targeted inhibition, using drugs such as NVP-231, in combination with conventional pro-apoptotic chemotherapy."
4.	Lung Neoplasms (Lung Cancer) 12/01/2014 - "The breast and lung cancer cell lines MCF-7 and NCI-H358 were treated with increasing concentrations of NVP-231 and DNA synthesis, colony formation and cell death were determined. " 12/01/2014 - "The ceramide kinase inhibitor NVP-231 inhibits breast and lung cancer cell proliferation by inducing M phase arrest and subsequent cell death."
5.	Inflammation (Inflammations) 01/01/2014 - "Here, we used a novel catalytic inhibitor of CerK, NVP-231, and CerK knockout cells to investigate the contribution of CerK to proliferation and inflammation in renal mesangial cells and fibroblasts. "

Related Drugs and Biologics

1.	ceramide kinase
2.	Small Interfering RNA (siRNA)
3.	Enzymes
4.	DNA (Deoxyribonucleic Acid)
5.	Cisplatin (Platino)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)