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apogossypolone

has antineoplastic activity; structure in first source

Also Known As:

ApoG2 cpd

Networked: 25 relevant articles (0 outcomes, 5 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Terpenes: 1461
    - Sesquiterpenes: 1370
      - Gossypol: 534
        apogossypolone: 25

Experts

1.	Yang, Dajun: 5 articles (09/2014 - 02/2008)
2.	Wu, Daocheng: 4 articles (06/2016 - 04/2009)
3.	Zhan, Yonghua: 3 articles (01/2018 - 04/2009)
4.	Sun, Jian: 3 articles (11/2015 - 07/2009)
5.	Hu, Zhe-Yu: 3 articles (07/2015 - 07/2009)
6.	Xu, Liang: 3 articles (01/2015 - 04/2009)
7.	Aboukameel, Amro: 3 articles (04/2010 - 02/2008)
8.	Chen, Jianyong: 3 articles (04/2010 - 02/2008)
9.	Mohammad, Ramzi M: 3 articles (04/2010 - 02/2008)
10.	Wang, Jing: 2 articles (08/2018 - 01/2011)

Related Diseases

1.	Lymphoma (Lymphomas) 02/14/2008 - "Preclinical studies of Apogossypolone: a new nonpeptidic pan small-molecule inhibitor of Bcl-2, Bcl-XL and Mcl-1 proteins in Follicular Small Cleaved Cell Lymphoma model." 07/01/2015 - "Apogossypolone induces reactive oxygen species accumulation and controls cell cycle progression in Raji Burkkit's lymphoma cells." 07/01/2009 - "We examined the effect of apogossypolone (ApoG2), a new derivative from gossypol on cell cycle regulation in U937 human leukemic monocyte lymphoma cells in vitro. " 02/14/2008 - "This prompted us to evaluate a very potent non-peptidic Small-Molecule Inhibitor (SMI) targeting Bcl-2 family proteins, Apogossypolone (ApoG2) using follicular small cleaved cell lymphoma cell line (WSU-FSCCL) and cell isolated from lymphoma patients. "
2.	Prostatic Neoplasms (Prostate Cancer) 01/01/2018 - "An interested reader drew to the attention of the Editorial Board of Molecular Medicine Reports that certain data in the above paper had already been published in a previous study featuring several of the same authors [Zhang XQ, Huang XF, Hu XB, Zhan YH, An QX, Yang SM, Xia AJ, Yi J, Chen R, Mu SJ and Wu DC: "Apogossypolone, a novel inhibitor of antiapoptotic Bcl-2 family proteins, induces autophagy of PC-3 and LNCaP prostate cancer cells in vitro". " 09/01/2010 - "Here we investigated the antiproliferative activity of apogossypolone (ApoG2) and (-)-gossypol on the human prostate cancer cell line PC3 and LNCaP in vitro. " 09/01/2010 - "Apogossypolone, a novel inhibitor of antiapoptotic Bcl-2 family proteins, induces autophagy of PC-3 and LNCaP prostate cancer cells in vitro."
3.	Nasopharyngeal Carcinoma 07/01/2017 - "Apogossypolone induces apoptosis and autophagy in nasopharyngeal carcinoma cells in an in vitro and in vivo study." 09/01/2014 - "Apogossypolone, a small-molecule inhibitor of Bcl-2, induces radiosensitization of nasopharyngeal carcinoma cells by stimulating autophagy."
4.	Pancreatic Neoplasms (Pancreatic Cancer) 04/01/2010 - "Apogossypolone, which functions as a potent pan-Bcl-2 family inhibitor, seems therapeutically promising for future translational studies including the treatment of pancreatic cancer." 04/01/2010 - "Preclinical studies of apogossypolone, a novel pan inhibitor of bcl-2 and mcl-1, synergistically potentiates cytotoxic effect of gemcitabine in pancreatic cancer cells."
5.	Multiple Myeloma 02/01/2009 - "This study was aimed to investigate the effects of apogossypolone (ApoG2) on proliferative inhibition and apoptotic induction of multiple myeloma cells and its mechanism. " 02/01/2009 - "[Effect of apogossypolone on induction apoptosis in multiple myeloma cells and its mechanisms]."

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Gemcitabine
3.	Gossypol
4.	Reactive Oxygen Species (Oxygen Radicals)
5.	Micelles
6.	Doxorubicin (Adriamycin)
7.	Copper
8.	Cadherins (E-Cadherin)
9.	Starch (Cornstarch)
10.	Ions

Related Therapies and Procedures

1.	Therapeutics
2.	Photochemotherapy (Photodynamic Therapy)
3.	Drug Therapy (Chemotherapy)