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3'- (5- (1- hydroxy- 1- methylethyl)benzoimidazol- 1- yl)biphenyl- 2- carbonitrile

an anxiolytic agent; structure in first source

Also Known As:

NS 11394; NS-11394; NS11394

Networked: 5 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzimidazoles: 245
      - 3'-(5-(1-hydroxy-1-methylethyl)benzoimidazol-1-yl)biphenyl-2-carbonitrile: 5

Experts

1.	Ahring, P K: 2 articles (12/2008 - 12/2008)
2.	Erichsen, H K: 2 articles (12/2008 - 12/2008)
3.	Larsen, J S: 2 articles (12/2008 - 12/2008)
4.	Mirza, N R: 2 articles (12/2008 - 12/2008)
5.	Munro, G: 2 articles (12/2008 - 12/2008)
6.	Nielsen, E Ø: 2 articles (12/2008 - 12/2008)
7.	Bauer, Anne: 1 article (11/2016)
8.	Gerstenberger, Julia: 1 article (11/2016)
9.	Richter, Angelika: 1 article (11/2016)
10.	Richter, Franziska: 1 article (11/2016)

Related Diseases

1.	Pain (Aches) 12/01/2012 - "The aim of the present paper was to study the effects of GABAA receptor-positive modulators (L-838417 and NS11394) showing a preference for α2/3 subunits of the GABAA receptor, in models of pain, anxiety, learning, memory and motor function. " 12/01/2008 - "The robust therapeutic window seen with NS11394 in animals suggests that compounds with this in vitro selectivity profile could have potential benefit in clinical treatment of pain in humans." 12/01/2012 - "Assessment of the effects of NS11394 and L-838417, α2/3 subunit-selective GABA(A) [corrected] receptor-positive allosteric modulators, in tests for pain, anxiety, memory and motor function." 12/01/2012 - "This was surprising as both NS11394 and TPA023 robustly attenuated late phase (6-30 min post-injection) capsaicin-induced flinching, a pain-like behaviour that is putatively driven by peripheral and central sensitizing mechanisms. "
2.	Neuralgia (Stump Neuralgia) 12/01/2008 - "Likewise, hindpaw mechanical allodynia was fully reversed by NS11394 in two rat models of peripheral neuropathic pain. " 12/01/2008 - "Comparison of the novel subtype-selective GABAA receptor-positive allosteric modulator NS11394 [3'-[5-(1-hydroxy-1-methyl-ethyl)-benzoimidazol-1-yl]-biphenyl-2-carbonitrile] with diazepam, zolpidem, bretazenil, and gaboxadol in rat models of inflammatory and neuropathic pain."
3.	Hypersensitivity (Allergy) 12/01/2012 - "The subtype-selective PAM NS11394 (0.3-10 mg/kg), and the non-selective PAM diazepam (1-5 mg/kg) variously reduced capsaicin-induced secondary mechanical hypersensitivity (180 min post-injection). "
4.	Hyperalgesia 12/01/2008 - "Likewise, hindpaw mechanical allodynia was fully reversed by NS11394 in two rat models of peripheral neuropathic pain. "
5.	Dystonia (Limb Dystonia) 11/15/2016 - "The α2β3γ2 GABAA receptor preferring agonist NS11394 aggravates dystonia in the phenotypic dtsz model." 11/15/2016 - "While zolpidem showed moderate beneficial effects, NS11394 significantly increased the severity of dystonia. " 11/15/2016 - "We therefore examined the effects of the α1β3γ2 GABAA receptor preferring compound zolpidem (2.0-10.0mg/kg i.p.) and of the α2β3γ2 GABAA receptor preferring compound NS11394 (3.0-30mg/kg i.p.) on the severity of dystonia in the dtsz mutant in comparison with the benzodiazepine clonazepam (0.5-1.0mg/kg i.p.). "

Related Drugs and Biologics

1.	Diazepam (Valium)
2.	Benzodiazepines
3.	Zolpidem (Ambien)
4.	gamma-Aminobutyric Acid (GABA)
5.	Clonazepam (Rivotril)
6.	Capsaicin (Zostrix)
7.	Ethanol (Ethyl Alcohol)
8.	7- (1,1- dimethylethyl)- 6- (2- ethyl- 2H- 1,2,4- triazol- 3- ylmethoxy)- 3- (2- fluorophenyl)- 1,2,4- triazolo(4,3- b)pyridazine
9.	L 838,417
10.	bretazenil