HOME PRODUCTS COMPANY CONTACT FAQ

Research Dictionary Pharma

Sign Up FREE or Login

7- chloro- 6- piperidin- 1- ylquinoline- 5,8- dione

has antineoplastic activity; structure in first source

Also Known As:

PT 262; PT-262; PT262 cpd

Networked: 2 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Quinones: 434
  - 7-chloro-6-piperidin-1-ylquinoline-5,8-dione: 2
Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Quinolines: 146
      - Quinolones: 2938
        7-chloro-6-piperidin-1-ylquinoline-5,8-dione: 2

Experts

1.	Chao, Jui-I: 2 articles (04/2011 - 10/2008)
2.	Chen, Chinpiao: 2 articles (04/2011 - 10/2008)
3.	Hsu, Tzu-Sheng: 2 articles (04/2011 - 10/2008)
4.	Liu, Huei-Fang: 2 articles (04/2011 - 10/2008)
5.	Tsai, Chih-Chien: 2 articles (04/2011 - 10/2008)
6.	Hsu, Kai-Cheng: 1 article (04/2011)
7.	Liu, Kuang-Kai: 1 article (04/2011)
8.	Yang, Jinn-Moon: 1 article (04/2011)
9.	Chiu, Shu-Jun: 1 article (10/2008)
10.	Lee, Pei-Ting: 1 article (10/2008)

Related Diseases

1.	Carcinoma (Carcinomatosis) 04/01/2011 - "In this study, we investigated a new compound derived from 5,8-quinolinediones, 7-chloro-6-piperidin-1-yl-quinoline-5,8-dione (designated as PT-262), which markedly induced cytoskeleton remodeling and migration inhibition in lung carcinoma cells. " 04/01/2011 - "PT-262 induced cytoskeleton remodeling and migration inhibition in A549 lung carcinoma cells. "
2.	Neoplasms (Cancer) 10/01/2008 - "Moreover, PT-262 did not alter the protein expression of tumor suppressor p53. "
3.	Lung Neoplasms (Lung Cancer) 10/01/2008 - "PT-262 suppresses the phosphorylation of ERK and CDC2 associated with proliferation inhibition via a p53-independent pathway in human lung cancer cells." 10/01/2008 - "PT-262 elicited the cytotoxicity and accumulated the G2/M fractions in both the p53-wild type and p53-null lung cancer cells. " 10/01/2008 - "Treatment with 1-20 microM PT-262 for 24 h induced cytotoxicity via a concentration-dependent manner in human lung cancer cells. " 10/01/2008 - "To examine the induction of apoptosis following PT-262 treatment, the lung cancer cells were subjected to apoptotic cell observation, caspase activation, and mitochondrial functional assays. "

Related Drugs and Biologics

1.	Caspases
2.	Proteins (Proteins, Gene)