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thiacarpine

a syntheic antineoplastic analog of cytotoxic marine alkaloid polycarpine; structure in first source

Also Known As:

bis(2-amino-4-(4-methoxyphenyl)-5-thiazolyl)disulfide dihydrochloride

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Alkaloids: 5398
  - thiacarpine: 1
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Imidazoles: 150
      - thiacarpine: 1

Experts

1.	Agafonova, Irina G: 1 article (07/2008)
2.	Aminin, Dmitry L: 1 article (07/2008)
3.	Novikov, Vyacheslav L: 1 article (07/2008)
4.	Radchenko, Oleg S: 1 article (07/2008)
5.	Stonik, Valentin A: 1 article (07/2008)

Related Diseases

1.	Neoplasms (Cancer) 07/01/2008 - "Thiacarpine in a total dose of 100 mg/kg was found to exhibit the delay in growth of the mouse tumor. " 07/01/2008 - "The anticancer effect of thiacarpine, a synthetic analogue of the known cytotoxic alkaloid polycarpine isolated from the Pacific ascidian Polycarpa aurata, was investigated in vivo in experiments using mouse solid Ehrlich carcinoma tumor as the target. "
2.	Necrosis 07/01/2008 - "Fluorescence microscopy and image analysis were applied to determine Ehrlich carcinoma cell chromatin condensing (apoptosis) and necrosis in Ehrlich carcinoma cells at the action of thiacarpine in in vitro experiments. "
3.	Carcinoma (Carcinomatosis) 07/01/2008 - "Our data show that the ability of thiacarpine to induce apoptosis in carcinoma cells may contribute to thiacarpine anticancer effects against mice solid Ehrlich carcinoma in vivo detected by MRI." 07/01/2008 - "Fluorescence microscopy and image analysis were applied to determine Ehrlich carcinoma cell chromatin condensing (apoptosis) and necrosis in Ehrlich carcinoma cells at the action of thiacarpine in in vitro experiments. " 07/01/2008 - "Magnetic resonance imaging of mouse Ehrlich carcinoma growth inhibition by thiacarpine, an analogue of cytotoxic marine alkaloid polycarpine." 07/01/2008 - "The anticancer effect of thiacarpine, a synthetic analogue of the known cytotoxic alkaloid polycarpine isolated from the Pacific ascidian Polycarpa aurata, was investigated in vivo in experiments using mouse solid Ehrlich carcinoma tumor as the target. "

Related Drugs and Biologics

1.	Chromatin
2.	Alkaloids
3.	polycarpine