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paclitaxel 2'-ethylcarbonate

structure in first source

Also Known As:

2'-ethylcarbonate-linked paclitaxel; TAX-2'-Et

Networked: 4 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Terpenes: 1461
    - Diterpenes: 1470
      - Taxoids: 2650
        Paclitaxel: 22016
        paclitaxel 2'-ethylcarbonate: 4
  - Cyclic Hydrocarbons: 97
    - Alicyclic Hydrocarbons: 1
      - Cycloparaffins: 6
        Cyclodecanes
        Taxoids: 2650
        Paclitaxel: 22016
        paclitaxel 2'-ethylcarbonate: 4

Experts

1.	Iwaki, Masahiro: 4 articles (02/2010 - 03/2007)
2.	Nawa, Akihiro: 4 articles (02/2010 - 03/2007)
3.	Tanino, Tadatoshi: 4 articles (02/2010 - 03/2007)
4.	Kikkawa, Fumitaka: 3 articles (02/2010 - 03/2007)
5.	Nishiyama, Yukihiro: 3 articles (02/2010 - 03/2007)
6.	Ino, Kazuhiko: 2 articles (02/2010 - 02/2008)
7.	Kajiyama, Hiroaki: 2 articles (02/2010 - 02/2008)
8.	Shibata, Kiyosumi: 2 articles (02/2010 - 02/2008)
9.	Tsurumi, Tatsuya: 2 articles (02/2010 - 03/2007)
10.	Yamamoto, Eiko: 2 articles (02/2010 - 02/2008)

Related Diseases

1.	Ovarian Neoplasms (Ovarian Cancer) 02/01/2008 - "We herein provide evidence that TAX-2'-Et could circumvent P-gp-associated cellular efflux of TAX, suggesting that this combination therapy is a potential GDEPT strategy for ovarian cancer in the future. " 07/01/2008 - "The Ra-CES enzyme is capable of hydrolysing TAX-2'-Et, which may be beneficial for the development of a TAX-2'-Et/enzyme therapy strategy for ovarian cancer."
2.	Neoplasms (Cancer) 03/01/2007 - "TAX-2'-Et is converted into TAX by the Ra-CES, supporting its potential use as a theoretical GDEPT strategy for cancer cells expressing high levels of P-gp. " 02/01/2010 - "This GDEPT system aims to produce high level of CES at the tumor site, resulting in efficient local conversion of the TAX-2'-Et prodrug into the active drug TAX [A. " 03/01/2007 - "The TAX-2'-Et prodrug efficiently increased the amount of intracellular TAX, which mediates tumor cell death."
3.	Carcinoma (Carcinomatosis) 03/01/2007 - "Transfection of Ra-CES into another TAX-resistant ovarian carcinoma cells (KOC-7c) conferred a high level of TAX-2'-Et cytotoxicity via prodrug activation. " 03/01/2007 - "TAX-2'-Et transport was characterized in a human colon carcinoma cell line (Caco-2) and paclitaxel (TAX)-resistant ovarian carcinoma cells (SKOV3/TAX60). "

Related Drugs and Biologics

1.	Enzymes
2.	Prodrugs
3.	Paclitaxel (Taxol)

Related Therapies and Procedures

1.	Enzyme Therapy
2.	Therapeutics