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BIX 02188

a MEK5 inhibitor; structure in first source

Also Known As:

BIX-02188; BIX02188

Networked: 5 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amines: 4871
  - Aniline Compounds: 46
    - BIX 02188: 5
Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Indoles: 200
      - BIX 02188: 5

Experts

1.	Wang, Chun-Guang: 3 articles (11/2015 - 04/2011)
2.	Zhang, Li-Cai: 3 articles (11/2015 - 04/2011)
3.	Ding, Yan-Ling: 2 articles (11/2015 - 05/2013)
4.	Liu, He: 2 articles (05/2013 - 04/2011)
5.	Wei, Jing-Qiu: 2 articles (05/2013 - 04/2011)
6.	Liu, Chen-Jun: 1 article (11/2019)
7.	Liu, Hai-Ying: 1 article (11/2019)
8.	Wang, Kai-Feng: 1 article (11/2019)
9.	Xia, Wei-Wei: 1 article (11/2019)
10.	Zhang, Yuan-Yuan: 1 article (11/2019)

Related Diseases

1.	Substance Withdrawal Syndrome (Withdrawal Symptoms) 05/01/2013 - "Moreover, selective attenuation of p-ERK5 expression in the CSF-CN by lateral ventricle injection of BIX02188 could significantly relieve morphine withdrawal symptom. " 04/20/2011 - "These findings suggested that activation of the ERK5 signaling pathway might contribute to morphine physical dependence and its specific pharmacological inhibitor BIX02188 could be a potential therapeutic choice for alleviation of morphine withdrawal symptoms in the future." 04/20/2011 - "Moreover, selective attenuation of spinal p-ERK5 expression by BIX02188 could significantly relieve morphine withdrawal symptom, accompanying with the decreased phosphorylation of cAMP response-element binding protein (CREB) in the spinal cord. "
2.	B-Cell Lymphoma (Lymphoma, B Cell) 11/05/2019 - "BIX02188 or DMSO was intra-thecally injected at 1, 6, and 12 h after surgery or SCI. Spinal cord samples were taken for testing at 24 h after surgery or SCI. Expression of phosphorylated-ERK5 (p-ERK5) significantly increased after SCI. Application of BIX02188 indeed inhibited ERK5 signaling pathway and reduced the degree of spinal cord tissue injury, neutrophil infiltration and proinflammatory cytokine expression, nuclear factor-κB (NF-κB) activation and apoptosis (measured by TdT-mediated 2'-deoxyuridine 5'-triphosphate nick-end labeling, expression of Fas-ligand, BCL2-associated X [Bax], and B-cell lymphoma-2 [Bcl-2]). "
3.	Wounds and Injuries (Trauma) 06/01/2015 - "Sprague-Dawley rats were randomly divided into the following 6 groups: control, trauma model, EA, sham EA, 4 nmol-BIX 02188 (an inhibitor for ERK 5 catalytic activity) and 20 nmol-BIX 02188 (n = 6 rats per group). "
4.	Hypersensitivity (Allergy) 11/01/2015 - "Moreover, selective inhibiting of p-ERK5 expression in CSF-CN by BIX02188 could significantly relieve CCI-induced mechanical allodynia and thermal hypersensitivity, accompanying with the decreased phosphorylation of cAMP response-element binding protein (CREB) in CSF-CN. "
5.	Hyperalgesia 11/01/2015 - "Moreover, selective inhibiting of p-ERK5 expression in CSF-CN by BIX02188 could significantly relieve CCI-induced mechanical allodynia and thermal hypersensitivity, accompanying with the decreased phosphorylation of cAMP response-element binding protein (CREB) in CSF-CN. "

Related Drugs and Biologics

1.	Cyclic AMP Response Element-Binding Protein (Cyclic AMP-Responsive DNA-Binding Protein)
2.	Morphine (MS Contin)
3.	Fas Ligand Protein (Fas Ligand)
4.	Cytokines
5.	Dimethyl Sulfoxide (DMSO)
6.	Deoxyuridine
7.	salicylhydroxamic acid (SHAM)
8.	triphosphoric acid (triphosphate)