|1.||Flück, Christa E: 5 articles (01/2015 - 08/2010)|
|2.||Hofer, Gaby: 5 articles (01/2015 - 08/2010)|
|3.||Mullis, Primus E: 5 articles (01/2015 - 08/2010)|
|4.||Hirsch, Andrea: 3 articles (09/2012 - 08/2010)|
|5.||Kempná, Petra: 3 articles (09/2012 - 08/2010)|
|6.||Sasano, Hironobu: 2 articles (06/2015 - 09/2004)|
|7.||Nakayama, Tomohiro: 2 articles (12/2012 - 10/2010)|
|8.||Shimodaira, Masanori: 2 articles (12/2012 - 10/2010)|
|9.||Sato, Naoyuki: 2 articles (12/2012 - 10/2010)|
|10.||Hahn, Dagmar: 2 articles (09/2012 - 01/2012)|
|1.||Polycystic Ovary Syndrome (Syndrome, Stein-Leventhal)
01/01/2013 - "Therefore, specific downregulation of HSD3B2 at adrenarche around age 6-8 years and characteristic upregulation of HSD3B2 in the ovaries of women suffering from the polycystic ovary syndrome remain unexplained prompting us to study the regulation of HSD3B2 in adrenal NCI-H295R cells. "
02/01/2004 - "The hormonal phenotype of Nonclassic 3 beta-hydroxysteroid dehydrogenase (HSD3B) deficiency in hyperandrogenic females is associated with insulin-resistant polycystic ovary syndrome and is not a variant of inherited HSD3B2 deficiency."
09/01/2012 - "Androgen biosynthesis requires steroid enzymes 17α-Hydroxylase/17,20 lyase (CYP17A1) and 3β-hydroxysteroid dehydrogenase type 2 (HSD3B2), which are overexpressed in ovarian cells of polycystic ovary syndrome women. "
02/01/2004 - "To test our hypothesis that the hormonal phenotype of mild 3beta-hydroxysteroid dehydrogenase (HSD3B) deficiency in hyperandrogenic females (HF) is related to insulin-resistant polycystic ovary syndrome (PCOS), we compared insulin sensitivity and gonadotropin secretion in HF with compromised ( downward arrow ) adrenal HSD3B phenotype despite normal HSD3B2 genes (n = 6) to those in HF with classic PCOS (n = 9) of similar ages (14-36 yr). "
03/01/2015 - "Our data provide evidence that pathogenic mutations can underlie both mild and severe hypospadias and that HSD3B2 mutations cause non-syndromic hypospadias as a sole clinical manifestation. "
03/01/2015 - "Seven of 62 patients with anterior or posterior hypospadias carried putative pathogenic mutations, such as hemizygous mutations in AR, a heterozygous mutation in BNC2, and homozygous mutations in SRD5A2 and HSD3B2. "
02/01/2004 - "We conclude that subtle molecular abnormalities in the HSD3B2 gene may be observed in some patients with apparent idiopathic hypospadias but that this finding is uncommon."
02/01/2004 - "To determine whether some patients with idiopathic hypospadias have HSD3B2 mutations, we genotyped this locus in 90 patients with hypospadias (age, 6.0 +/- 0.4 yr) and 101 healthy fertile male controls. "
05/01/2012 - "Studies screening groups of patients with hypospadias for single gene defects found mutations in WT1, SF1, BMP4, BMP7, HOXA4, HOXB6, FGF8, FGFR2, AR, HSD3B2, SRD5A2, ATF3, MAMLD1, MID1 and BNC2. "
|3.||Inborn Genetic Diseases (Disease, Hereditary)
|4.||Congenital Adrenal Hyperplasia (Hyperplasia, Congenital Adrenal)
08/01/2015 - "Zebrafish hsd3b1(Dre 9), on the contrary, functions like mammalian HSD3B2, whose deficiency leads to congenital adrenal hyperplasia. "
08/01/2015 - "Individuals lacking HSD3B2 activity experience congenital adrenal hyperplasia with imbalanced steroid synthesis. "
01/01/2015 - "3βHSD2 deficiency is a rare cause of congenital adrenal hyperplasia caused by recessive loss-of-function HSD3B2 mutations. "
01/01/2015 - "A novel missense mutation in the HSD3B2 gene, underlying nonsalt-wasting congenital adrenal hyperplasia. "
01/01/2012 - "HSD3B2 mutations cause the rare form of congenital adrenal hyperplasia '3βHSD deficiency'. "
|5.||Prostatic Neoplasms (Prostate Cancer)
06/01/2009 - "Genetic variants within HSD3B2 and CYP24A1 conferred increased risk of prostate cancer in non-Hispanic or Hispanic Caucasians. "
11/01/2007 - "In Caucasians, the HSD3B2 (TG)n,(TA)n,(CA)n intron 3 length polymorphism is associated with both prostate cancer risk and aggressiveness and the SRD5A2 V89L polymorphism may modify the risk conferred by this polymorphism."
11/01/2007 - "Stratified analyses revealed that most of the prostate cancer risk associated with the intron 3 HSD3B2 short allele was confined to the SRD5A2 89L variant subgroup and indicated that in combination these polymorphisms may be associated with increased risk of aggressive (Gleason >7) disease (Gleason >7). "
11/01/2007 - "Carriage of at least one HSD3B2 intron 3 intron 3 short allele was associated with a significant increased risk for prostate cancer among all subjects (OR = 2.07, 95% CI = 1.08-3.95, P = 0.03) and Caucasians (OR = 2.80, CI = 2.80-7.43, P = 0.04), but not in African Americans (OR = 1.50, CI = 0.62-3.60, P = 0.37). "
11/01/2007 - "SRD5A2 and HSD3B2 polymorphisms are associated with prostate cancer risk and aggressiveness."
|3.||Steroid 17-alpha-Hydroxylase (17 alpha Hydroxylase)
|4.||Messenger RNA (mRNA)
|6.||DNA (Deoxyribonucleic Acid)
|7.||Cholesterol Side-Chain Cleavage Enzyme (CYP11A1)
|9.||Cytochrome P-450 CYP1A1 (CYP1A1)
|10.||3-Hydroxysteroid Dehydrogenases (3 beta Hydroxysteroid Dehydrogenase)