|1.||Touvay, Caroline: 1 article (10/2008)|
|2.||Chabrier, Pierre-Etienne: 1 article (10/2008)|
|3.||Favre-Guilmard, Christine: 1 article (10/2008)|
|4.||Prevost, Grégoire: 1 article (10/2008)|
|5.||Zeroual-Hider, Hamida: 1 article (10/2008)|
|6.||Soulard, Chantal: 1 article (10/2008)|
|7.||Auguet, Michel: 1 article (10/2008)|
10/10/2008 - "Since many mediators of pain act through G-protein coupled receptors, the anti-hyperalgesic effects of BIM-46187 were assessed on experimental models of pain. "
10/10/2008 - "This work highlights the role of heterotrimeric G-protein complexes in pain and supports further investigations of the use of BIM-46187 alone, or in combination with low doses of morphine, in the management of pain."
10/10/2008 - "In addition since opioids are widely used in pain management and act through specific G-protein-coupled receptors, the effects of BIM-46187 on the analgesic properties of morphine have also been investigated. "
10/10/2008 - "BIM-46187 elicited a dose dependent analgesic effect in the models of carrageenan-induced hyperalgesia (0.1-1 mg/kg; i.v.) and chronic constriction injury (0.3-3 mg/kg; i.v.) in rats. "
10/10/2008 - "The combination of BIM-46187 and morphine (ratio 1/1) resulted in an unexpected synergistic effect in the model of carrageenan-induced hyperalgesia and in the chronic constriction injury model in rats when evaluated by isobolographic analysis. "
|1.||G-Protein-Coupled Receptors (Receptors, G Protein Coupled)
|2.||GTP-Binding Proteins (G-Protein)
|3.||Morphine (MS Contin)
|5.||Opioid Analgesics (Opioids)