|1.||Perea, Silvio E: 13 articles (06/2015 - 10/2004)|
|2.||Perera, Yasser: 10 articles (06/2015 - 01/2008)|
|3.||Alonso, Daniel F: 10 articles (06/2014 - 10/2004)|
|4.||Reyes, Osvaldo: 6 articles (02/2015 - 10/2004)|
|5.||Acevedo, Boris E: 5 articles (04/2012 - 01/2008)|
|6.||Besada, Vladimir: 4 articles (02/2015 - 09/2008)|
|7.||Farina, Hernán G: 4 articles (06/2014 - 01/2008)|
|8.||Gil, Jeovanis: 4 articles (10/2011 - 09/2008)|
|9.||Falcón, Viviana: 3 articles (06/2015 - 10/2004)|
|10.||Gomez, Daniel E: 3 articles (06/2014 - 07/2011)|
05/12/2015 - "We conducted a phase 1 trial in patients with locally advanced cervical cancer by injecting 0.5 ml of the CK2-antagonist CIGB-300 in two different sites on tumours to assess tumour uptake, safety, pharmacodynamic activity and identify the recommended dose. "
06/02/2014 - "CIGB-300 is a cyclic synthetic peptide that induces apoptosis in malignant cells, elicits antitumor activity in cancer animal models, and shows tumor reduction signs when assayed in first-in-human phase I trial in patients with cervical tumors. "
01/15/2014 - "CIGB-300 is a cell-permeable selective CK2 inhibitor peptide undergoing clinical trials for several cancers. "
01/01/2009 - "Based on the perspectives of CIGB-300 to treat cancer, this "first-in-human" study investigated its safety and tolerability in patients with cervical malignancies. "
05/12/2015 - "Optimizing CIGB-300 intralesional delivery in locally advanced cervical cancer."
|2.||Lung Neoplasms (Lung Cancer)
06/01/2015 - "In this work, we sought to identify the biological processes modulated by CIGB-300 in a lung cancer cell line using subtractive suppression hybridization and subsequent functional annotation clustering. "
04/01/2012 - "Interestingly, we had previously demonstrated that the putative oncogene B23/nucleophosmin (NPM) is the major intracellular target for CIGB-300 in a sensitive human lung cancer cell line. "
|3.||B-Cell Chronic Lymphocytic Leukemia (Chronic Lymphocytic Leukemia)
|4.||Neoplasm Metastasis (Metastasis)
|3.||Proteins (Proteins, Gene)
|1.||Heterologous Transplantation (Xenotransplantation)