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PF 00477736

a Chk1 inhibitor; structure in first source

Also Known As:

PF-00477736; PF-477736; PF00477736; PF477736

Networked: 11 relevant articles (0 outcomes, 3 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Pyrazoles: 61
      - PF 00477736: 11
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzazepines: 5
      - Benzodiazepines: 8452
        Benzodiazepinones
        PF 00477736: 11

Experts

1.	Ando, Kiyohiro: 2 articles (01/2020 - 07/2019)
2.	Koshinaga, Tsugumichi: 2 articles (01/2020 - 07/2019)
3.	Makishima, Makoto: 2 articles (01/2020 - 07/2019)
4.	Nagase, Hiroki: 2 articles (01/2020 - 07/2019)
5.	Wada, Satoshi: 2 articles (01/2020 - 07/2019)
6.	Cázares-Ordoñez, Verna: 1 article (01/2020)
7.	Kamijo, Takehiko: 1 article (01/2020)
8.	Kobayashi, Shinichi: 1 article (01/2020)
9.	Suenaga, Yusuke: 1 article (01/2020)
10.	Yokoyama, Atsushi: 1 article (01/2020)

Related Diseases

1.	Neoplasms (Cancer) 07/13/2018 - "Mouse xenograft studies show that treating A375-PLX-R derived tumors with combined PLX4032 and PF477736 significantly reduce tumor growth. " 07/15/2009 - "In contrast, bioluminescence imaging showed that PF-00477736 sensitized docetaxel-induced suppression of tumor survival. " 07/15/2009 - "PF-00477736 significantly enhanced the docetaxel-induced efficacy in tumor cells and xenografts. " 08/07/2014 - "The Chk1 inhibitors V158411, PF-477736 and AZD7762 potently inhibited the proliferation of triple-negative breast cancer cells as well as ovarian cancer cells, and these cell lines were sensitive compared to ER positive breast and other solid cancer cells lines. "
2.	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma (T-ALL) 11/05/2015 - "The effectiveness of PF-00477736 as single agent in B-/T-ALL was evaluated in vitro and in vivo studies as a single agent. " 11/05/2015 - "Moreover, treatment with PF-00477736 showed efficacy ex vivo in primary leukemic blasts separated from 14 adult ALL patients and in vivo in mice transplanted with T-ALL, arguing in favor of its future clinical evaluation in leukemia. "
3.	Neuroblastoma 01/01/2020 - "In this study, we discovered that PF-477736 increased expression of MDM2 oncogene along with CHK1i-induced replication defects in neuroblastoma NB-39-nu cells. "
4.	Triple Negative Breast Neoplasms 11/10/2017 - "Associating PF477736 with teriflunomide also significantly sensitised SUM159 and HCC1937 human triple negative breast cancer cell lines to dihydroorotate dehydrogenase inhibition. " 08/07/2014 - "The Chk1 inhibitors V158411, PF-477736 and AZD7762 potently inhibited the proliferation of triple-negative breast cancer cells as well as ovarian cancer cells, and these cell lines were sensitive compared to ER positive breast and other solid cancer cells lines. " 10/01/2011 - "Luminal, HER2 overexpressing, and triple negative breast cancer-derived cells were tested for sensitivity to killing by PARP inhibitors, ABT-888 and BSI-201, and Chk1 inhibitor, PF-00477736, alone or in combination with gemcitabine or carboplatin. "
5.	Leukemia 11/05/2015 - "Moreover, treatment with PF-00477736 showed efficacy ex vivo in primary leukemic blasts separated from 14 adult ALL patients and in vivo in mice transplanted with T-ALL, arguing in favor of its future clinical evaluation in leukemia. " 01/01/2015 - "Interactions between the dual BCR/ABL and Src inhibitor bosutinib and the Chk1 inhibitor PF-00477736 were examined in BCR/ABL(+) leukemia cells, particularly imatinib-resistant cells, including those with the T315I mutation. "

Related Drugs and Biologics

1.	Vemurafenib
2.	Gemcitabine
3.	3- (carbamoylamino)- 5- (3- fluorophenyl)- N- (3- piperidyl)thiophene- 2- carboxamide
4.	Protein Serine-Threonine Kinases (Protein-Serine-Threonine Kinase)
5.	Carboplatin (JM8)
6.	Proteins (Proteins, Gene)
7.	Phenobarbital (Luminal)
8.	DNA (Deoxyribonucleic Acid)
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