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2- ((3,5- bis(trifluoromethylphenyl))hydroxymethyl)- 2- (4- nitrophenylamino)- 6- phenyl- 1,2,4a,7a- tetrahydropyrrolo(3,4- b)pyridine- 5,7- dione

inhibits JAK/STAT signaling; structure in first source

Also Known As:

AUH-6-96

Networked: 1 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Bach, Erika A: 1 article (09/2008)
2.	Baeg, Gyeong-Hun: 1 article (09/2008)
3.	Guo, Qianxu: 1 article (09/2008)
4.	Hall, Dennis G: 1 article (09/2008)
5.	Jayabose, Somasundaram: 1 article (09/2008)
6.	Kim, Byung Hak: 1 article (09/2008)
7.	Lee, Haeryun: 1 article (09/2008)
8.	Sandoval, Claudio: 1 article (09/2008)
9.	Ulaczyk-Lesanko, Agnieszka: 1 article (09/2008)
10.	Yin, Chang-Hong: 1 article (09/2008)

Related Diseases

1.	Neoplasms (Cancer) 09/01/2008 - "In summary, this study shows that AUH-6-96 is a novel small-molecule inhibitor of JAK/STAT signaling and may have therapeutic potential in the treatment of human cancers harboring aberrant JAK/STAT signaling." 09/01/2008 - "In support of the specificity of AUH-6-96 for inhibition of JAK/STAT signaling, treatment with AUH-6-96 decreased cancer cell survival by inducing programmed cell death by down-regulating the expression of STAT3 downstream target antiapoptotic genes, such as Bcl-xL. " 09/01/2008 - "Importantly, AUH-6-96 selectively affected cell viability only of cancer cells harboring aberrant JAK/STAT signaling. " 09/01/2008 - "In human cancer cell lines, AUH-6-96 inhibited both constitutive and interleukin-6-induced STAT3 phosphorylation. "
2.	Hodgkin Disease (Hodgkin's Disease) 09/01/2008 - "Specifically, in Hodgkin lymphoma L540 cells, treatment with AUH-6-96 resulted in reduced levels of tyrosine phosphorylated STAT3 and of the STAT3 downstream target gene SOCS3 in a dose- and time-dependent manner. "

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