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4-iodo-6-phenylpyrimidine

acts on macrophage migration inhibitory factor; structure in first source

Also Known As:

4-IPP cpd

Networked: 12 relevant articles (2 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrimidines: 510
    - 4-iodo-6-phenylpyrimidine: 12

Experts

1.	Mitchell, Robert A: 2 articles (03/2013 - 09/2008)
2.	Rendon, Beatriz E: 2 articles (03/2013 - 09/2008)
3.	Chen, Jian: 1 article (01/2022)
4.	Chen, Yilei: 1 article (01/2022)
5.	Feng, Zhenhua: 1 article (01/2022)
6.	Gao, Jiawei: 1 article (01/2022)
7.	Huang, Bao: 1 article (01/2022)
8.	Lin, Ye: 1 article (01/2022)
9.	Liu, Junhui: 1 article (01/2022)
10.	Shan, Zhi: 1 article (01/2022)

Related Diseases

1.	Inflammation (Inflammations) 01/01/2021 - "Treatment the lesion sites with MIF inhibitor 4-Iodo-6-phenylpyrimidine (4-IPP) reduced TGF-β1 production and relieved joint capsule inflammation and fibrosis. " 02/01/2023 - "4-Iodo-6-phenylpyrimidine (4-IPP) suppresses fibroblast-like synoviocyte- mediated inflammation and joint destruction associated with rheumatoid arthritis."
2.	Spinal Cord Injuries (Spinal Cord Injury) 08/01/2023 - "Administration of the macrophage migration inhibitory factor inhibitor 4-iodo-6-phenylpyrimidine following spinal cord injury resulted in the reduction of chemokine C-C motif chemokine ligand 2-recruited microglia/macrophages at the lesion site and remarkably improved the hindlimb locomotor function of rats. "
3.	Fibrosis (Cirrhosis) 01/01/2021 - "Treatment the lesion sites with MIF inhibitor 4-Iodo-6-phenylpyrimidine (4-IPP) reduced TGF-β1 production and relieved joint capsule inflammation and fibrosis. "
4.	Squamous Cell Carcinoma (Epidermoid Carcinoma) 07/01/2013 - "The present study was undertaken to examine the effects of the irreversible MIF inhibitor 4-iodo-6-phenylpyrimidine (4-IPP) on proliferation and invasiveness of the squamous carcinoma cell line SCCVII. "
5.	Adenocarcinoma of Lung 09/15/2008 - "Our studies further reveal that this compound, 4-iodo-6-phenylpyrimidine (4-IPP), is approximately 5x to 10x times more potent in blocking MIF-dependent catalysis and lung adenocarcinoma cell migration and anchorage-independent growth than the prototypical MIF inhibitor, ISO-1. "

Related Drugs and Biologics

1.	Macrophage Migration-Inhibitory Factors
2.	CC Chemokines
3.	Chemokines
4.	Ligands
5.	DDT
6.	Melatonin
7.	Chloroquine (Aralen)
8.	3- (2,4- dichloro- 5- methoxyphenyl)- 2- sulfanyl- 4(3H)- quinazolinone
9.	dopachrome isomerase
10.	chloroquine diphosphate