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(R,S)- 5,7- di- tert- butyl- 3- hydroxy- 3- trifluoromethyl- 3H- benzofuran- 2- one

a positive allosteric modulator of GABAB receptors; structure in first source

Also Known As:

rac-BHFF

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzofurans: 26
      - (R,S)-5,7-di-tert-butyl-3-hydroxy-3-trifluoromethyl-3H-benzofuran-2-one: 2

Experts

1.	Benke, Dietmar: 1 article (01/2016)
2.	Malherbe, Pari: 1 article (01/2016)
3.	Ralvenius, William T: 1 article (01/2016)
4.	Zemoura, Khaled: 1 article (01/2016)
5.	Cheng, Kejun: 1 article (10/2010)
6.	France, Charles P: 1 article (10/2010)
7.	Koek, Wouter: 1 article (10/2010)
8.	Rice, Kenner C: 1 article (10/2010)

Related Diseases

1.	Neuralgia (Stump Neuralgia) 01/01/2016 - "Here we tested the high affinity positive allosteric modulator rac-BHFF for its ability to relief neuropathic pain induced by chronic constriction of the sciatic nerve in mice. "
2.	Hypothermia 10/01/2010 - "The results provide evidence that CGP7930 and rac-BHFF act in vivo as positive modulators at GABA(B) receptors mediating loss of righting, but not at GABA(B) receptors mediating hypothermia. " 10/01/2010 - "In contrast with baclofen- and GHB-induced loss of righting, the hypothermic effects of baclofen and GHB were not enhanced by rac-BHFF but were enhanced by CGP7930 only at doses that produced hypothermia when given alone. "
3.	Hyperalgesia 01/01/2016 - "However, activation of spinal GABAB receptors by intrathecal injection of baclofen reduced hyperalgesia and its analgesic effect was considerably potentiated by co-application of rac-BHFF. "

Related Drugs and Biologics

1.	Baclofen
2.	GABA-B Receptors
3.	Analgesics (Analgesic Drugs)
4.	2,6- di- tert- butyl- 4- (3- hydroxy- 2,2- dimethylpropyl)phenol

Related Therapies and Procedures

1.	Spinal Injections