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6-O-angeloylenolin

isolated from Centipeda minima; structure in first source

Networked: 3 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Terpenes: 1461
    - Sesquiterpenes: 1370
      - 6-O-angeloylenolin: 3
- Lactones: 1549
  - 6-O-angeloylenolin: 3

Experts

1.	He, Qing-Yu: 1 article (01/2017)
2.	Hu, Hui-Fang: 1 article (01/2017)
3.	Huang, Zhi-Hao: 1 article (01/2017)
4.	Li, Bin: 1 article (01/2017)
5.	Li, Yao-Lan: 1 article (01/2017)
6.	Wang, Yang: 1 article (01/2017)
7.	Yu, Ru-Yuan: 1 article (01/2017)
8.	Zhang, Jing: 1 article (01/2017)
9.	Zhang, Wei-Xia: 1 article (01/2017)
10.	Chung, Hau Yin: 1 article (02/2011)

Related Diseases

1.	Nasopharyngeal Neoplasms (Cancer of the Nasopharynx) 02/01/2011 - "6-O-Angeloylenolin induced cell-cycle arrest and apoptosis in human nasopharyngeal cancer cells." 02/01/2011 - "This study investigated the anticancer activity of 6-O-angeloylenolin, a plant-derived sesquiterpene lactone, on human nasopharyngeal cancer (CNE) cells. "
2.	Leukemia 07/01/2008 - "6-O-Angeloylenolin induces apoptosis through a mitochondrial/caspase and NF-kappaB pathway in human leukemia HL60 cells." 07/01/2008 - "In this study, we demonstrated that 6-O-angeloylenolin could induce apoptosis in human leukemia HL60 cells through stimulating the generation of reactive oxygen species, decreasing mitochondrial trans-membrane potential (DeltaPsim) and activating caspase-3/7. We also found that 6-O-angeloylenolin could inhibit nuclear translocation of NF-kappaB and modulate the expression of Bcl-2 gene family. "
3.	Neoplasms (Cancer) 07/01/2008 - "Furthermore, we confirmed that 6-O-angeloylenolin could obviously inhibit the solid cancer growth in Lewis lung cancer xenograft models." 07/01/2008 - "6-O-Angeloylenolin, a sesquiterpene lactone from Centipeda minima, has been known to have anti-tumor activity against human colorectum, liver, stomach, lung, and skin tumor cells. "
4.	Lung Neoplasms (Lung Cancer) 07/01/2008 - "Furthermore, we confirmed that 6-O-angeloylenolin could obviously inhibit the solid cancer growth in Lewis lung cancer xenograft models."
5.	Adenocarcinoma of Lung 01/01/2017 - "Inhibition of Nrf2 enhances the anticancer effect of 6-O-angeloylenolin in lung adenocarcinoma."

Related Drugs and Biologics

1.	Sesquiterpenes
2.	Lactones
3.	Caspase 3 (Caspase-3)
4.	Reactive Oxygen Species (Oxygen Radicals)
5.	NF-kappa B (NF-kB)
6.	Caspases