Familial ependymoma

01/01/2022 - "The etiology is largely unknown and germline DNA sequencing studies focusing on childhood ependymoma are limited. "

12/01/2022 - "It is also reported efficacious against numerous other cancers and non-cancerous diseases including acute lung injury, dementia, Parkinson's disease, childhood ependymoma, and Krabbe disease etc. Carmofur also possesses antifungal and antimicrobial properties. "
11/01/2022 - "Recently, carmofur has gained attention as an acid ceramidase inhibitor and as a potential lead compound against several noncancerous diseases such as coronavirus disease 2019, Krabbe disease, acute lung injury, Parkinson's disease, dementia, childhood ependymoma etc. Carmofur has also been reported to have antifungal, and antimicrobial properties. "

11/01/2022 - "Recently, carmofur has gained attention as an acid ceramidase inhibitor and as a potential lead compound against several noncancerous diseases such as coronavirus disease 2019, Krabbe disease, acute lung injury, Parkinson's disease, dementia, childhood ependymoma etc. Carmofur has also been reported to have antifungal, and antimicrobial properties. "

07/01/2011 - "mTORC1 activation in childhood ependymoma and response to sirolimus."

10/01/2008 - "Furthermore, telomerase reactivation and maintenance of telomeric repeats appear necessary for childhood ependymoma progression. "

01/01/1991 - "It is concluded that the use of adjuvant chemotherapy with CCNU, vincristine, and cisplatinum does not improve progression-free survival in childhood ependymoma, and that the extent of surgical resection is a major determinant of outcome in this disease."

07/01/2019 - "The developed assay is now being utilised in a clinical trial involving the treatment of childhood ependymoma patients with valproic acid."

11/01/2020 - "Single-Cell RNA Sequencing of Childhood Ependymoma Reveals Neoplastic Cell Subpopulations That Impact Molecular Classification and Etiology."

07/15/2008 - "Proton radiotherapy for childhood ependymoma: initial clinical outcomes and dose comparisons."

07/01/2008 - "EGFR tyrosine kinase inhibition radiosensitizes and induces apoptosis in malignant glioma and childhood ependymoma xenografts."

10/01/2009 - "With more than a decade of experience, the role of conformal radiation therapy in the treatment of childhood ependymoma has been firmly established as investigators consider new trials to increase disease control and improve functional outcomes."
08/01/2004 - "We conducted a phase II trial of conformal radiation therapy (CRT) for localized childhood ependymoma to determine whether the irradiated volume could be reduced to decrease CNS-related side effects without diminishing the rate of disease control. "
07/15/2010 - "Investigating verbal and visual auditory learning after conformal radiation therapy for childhood ependymoma."
03/01/2010 - "to retrospectively determine the long-term outcome of adult intracranial ependymoma patients treated with surgery, reoperation, and postoperative radiation therapy. "
07/15/2008 - "Intensity-modulated radiation therapy in childhood ependymoma."

04/23/2016 - "Survival outcomes in response to chemotherapy in adult intracranial ependymoma patients vary substantially, but individual patients may respond to any kind of chemotherapy. "
10/01/2009 - "New chemotherapy strategies and biological agents in the treatment of childhood ependymoma."
05/01/2006 - "Childhood ependymoma remains a major therapeutic challenge despite surgery, chemotherapy, and irradiation. "
04/01/2004 - "Hyperfractionated radiotherapy and chemotherapy for childhood ependymoma: final results of the first prospective AIEOP (Associazione Italiana di Ematologia-Oncologia Pediatrica) study."
06/01/1990 - "Adjunctive treatment for recurrent childhood ependymoma of the IV ventricle: chemotherapy with CDDP and MCNU."

03/11/2022 - "Adjuvant radiotherapy in adult intracranial ependymoma: in any case?"
07/01/2020 - "Adult intracranial ependymoma is rare, and the role for adjuvant radiotherapy (RT) is not well defined. "
04/01/2014 - "Timing of adjuvant radiotherapy and treatment outcome in childhood ependymoma."

08/01/2006 - "Salvage treatment for childhood ependymoma after surgery only: Pitfalls of omitting "at once" adjuvant treatment."
02/01/2016 - " investigated the response, survival, and correlation with MGMT promoter methylation in a cohort of patients with adult intracranial ependymoma receiving TMZ as salvage therapy after failure of surgery and radiotherapy. "

01/01/2013 - "New molecularly targeted therapies are needed for childhood ependymoma. "
06/01/2007 - "Prognostic factors and optimal therapy for adult intracranial ependymoma are still debated. "