Biotin deficiency

12/01/2020 - "In the present study, we assess the infectivity of a biotin deficiency mutant (ΔbioB) and a complementation strain (CP36) on citrus leaves to determine how biotin impacts A. "
07/09/2015 - "With biotin deficiency being involved in various metabolic disorders, this study provides valuable insight into the metabolic effects biotin exerts on eukaryotic cells. "
07/01/2005 - "Recent studies of biotin status during pregnancy provide evidence that a marginal degree of biotin deficiency develops in a substantial proportion of women during normal pregnancy. "
03/01/1999 - "On the basis of studies using these indicators of biotin deficiency, an adequate intake of 30 microg (123 nmoles) of biotin per day is currently recommended for adults. "
06/01/1997 - "The apparent conflict in the indices of biotin status is not explained by this study but could be resolved by two alternate explanations: 1) Pregnancy caused an impairment of renal reclamation of biotin, BNB, and BSO leading to a paradoxical increase in biotin excretion 2) Pregnancy caused metabolic or renal effects that increased 3-HIA excretion nonspecifically; hence, the increased 3-HIA excretion did not reflect biotin deficiency. "

03/01/2011 - "This study provides evidence that urinary excretion of 3HIA-carnitine is an early and sensitive indicator of marginal biotin deficiency. "
12/01/2010 - "The ease of sample collection, small sample volume requirement, and stability of 3HIA-carnitine during storage suggest that plasma 3HIA-carnitine concentration is likely to be a useful indicator of marginal biotin deficiency for larger population studies."
12/01/2010 - "These studies provide evidence that 3HIA-carnitine is an early and sensitive indicator of marginal biotin deficiency. "
03/01/2005 - "Urinary 3-HIA could be assayed within the range of 0.42-8.5 mmol/L with high accuracy by this method, as an indicator of biotin deficiency. "
01/01/2005 - "These data provide evidence that expression of SLC19A3 is a relatively sensitive indicator of marginal biotin deficiency."

01/01/2015 - "In this study we hypothesized that coexisting carnitine deficiency can prevent the increase in 3HIAc due to biotin deficiency. "
01/01/2015 - "In HepG2 cells, coexisting carnitine deficiency masks important indicators of marginal biotin deficiency."
06/01/2013 - "Analyses of carnitine profiles of dried blood spots and urine 3-HIVA are relatively non-invasive and useful for the early detection of biotin deficiency in preterm infants."
02/20/2022 - "Relevance of Biotin Deficiency in Patients with Inflammatory Bowel Disease and Utility of Serum 3 Hydroxyisovaleryl Carnitine as a Practical Everyday Marker."
08/01/2016 - "Evidence of inborn metabolic diseases was absent, therefore biotin deficiency and carnitine deficiency were concluded to be a consequence of reliance on a HF for a prolonged period. "

04/01/2012 - "However, the different experimental models used in these studies make it difficult to integrate the effects of biotin deficiency on glucose metabolism. "
03/01/1962 - "Impairment of glucose utilization in biotin deficiency."
04/01/2012 - "Effects of biotin deficiency on pancreatic islet morphology, insulin sensitivity and glucose homeostasis."
07/01/2005 - "Biotin deficiency has been linked to impaired glucose tolerance and decreased utilization of glucose. "
04/01/2012 - "To further investigate the effects of biotin deficiency on glucose metabolism, we presently analyzed the effect of biotin deprivation on glucose homeostasis and on pancreatic islet morphology. "

01/01/1999 - "With the use of improved methods for measuring biotin and metabolites, a recent study indicated that decreased urinary excretion of biotin and bisnorbiotin is an early and sensitive indicator of biotin deficiency, but decreased serum concentration of biotin is not. "
01/01/2006 - "Biotin deficiency was associated with increased expression of a gene cluster encoding ribosomal subunits and eukaryotic translation initiation factor 5A; this effect was reversed by supplementation with biotin and bisnorbiotin. "
03/01/1999 - "Recent studies suggest that the urinary excretions of biotin and its metabolite bisnorbiotin, activities of propionyl-CoA carboxylase and beta-methylcrotonyl-CoA carboxylase in lymphocytes, and urinary excretion of 3-hydroxyisovaleric acid are good indicators of marginal biotin deficiency. "

01/01/2016 - "We also examined the effect of chronic biotin deficiency on permeability and expression of TJ proteins in confluent intestinal epithelial Caco-2 monolayers but observed no changes in these parameters. "
03/01/2010 - "It is suggested that the expression of these proteins may be downregulated by biotin deficiency, inducing the inhibited development of palatal processes."
08/01/1995 - "The results indicate that biotin deficiency may interfere directly with synthesis of specific proteins and the formation of palatal processes."
09/01/1983 - "Activity of GP was further decreased by biotin deficiency on the low-protein regimen and FAS and CCE were further increased. "
01/01/1979 - "Factors affecting protein synthesis during biotin deficiency in Aspergillus nidulans."

05/01/1989 - "These data demonstrate that biotin deficiency results in dramatic changes in the fatty acid composition of specific phospholipids in chick erythrocytes and heart subcellular organelles."
12/01/1987 - "Biotin deficiency resulted in elevated 18:3 omega 6 in liver and heart lipids and decreased 20:3 omega 6 in liver phospholipids. "
11/01/1984 - "Protein-calorie deficiency alone was primarily responsible for reduced levels of 22:5 omega 6. Biotin deficiency alone caused significant increases in liver phospholipids 18:3 omega 3 and 22:6 omega 3."
11/01/1984 - "Biotin deficiency caused significantly increased concentrations of 15:0, 17:0 and total odd-chain fatty acids in liver phospholipids. "
01/01/1989 - "3. Biotin deficiency resulted in proportionately higher levels of 18:2 omega 6 and gamma-linolenate (18:3 omega 6) in liver triglycerides, and lower levels of dihomo-gamma-linolenate (20:3 omega 6) in liver and heart phospholipids irrespective of the 18:2 omega 6 level in the diet. "

01/01/1993 - "This suggests that ascorbic acid may be consumed in the improvement of the metabolic impairments induced by biotin deficiency."
01/01/1993 - "The biological consequences of biotin deficiency in rats were investigated using osteogenic disorder Shionogi rats which have a hereditary defect in ascorbic acid synthesizing ability. "
11/01/1962 - "Ascorbic acid synthesis and biotin deficiency."
10/28/1953 - "[Protection by ascorbic acid against biotin deficiency in the rat]."
01/01/1993 - "On the other hand, in the case of rats fed a diet containing 500 mg ascorbic acid, although the clinical features of biotin deficiency developed, the ascorbic acid contents of liver and adrenal gland increased in comparison with those of AsA 200 mg groups, and the alterations of plasma levels of glucose and NEFA were improved partially in glucose and greatly in NEFA, respectively. "

01/01/1993 - "On the other hand, in the case of rats fed a diet containing 500 mg ascorbic acid, although the clinical features of biotin deficiency developed, the ascorbic acid contents of liver and adrenal gland increased in comparison with those of AsA 200 mg groups, and the alterations of plasma levels of glucose and NEFA were improved partially in glucose and greatly in NEFA, respectively. "
03/01/1988 - "In three patients who developed biotin deficiency during parenteral alimentation, serum fatty acid compositions of the four major lipid classes (phospholipid, cholesteryl ester, triglyceride and free fatty acid) were measured. "

11/01/1984 - "Biotin deficiency caused significant reduction in liver phospholipid 20:3 omega 6. Reduced arachidonic acid (20:4 omega 6) level was due to combined biotin protein-calorie deficiency. "

09/01/2003 - "Since the brain is quite vulnerable to biotin deficiency, delayed biotin therapy could result in neurological damage. "
03/01/1998 - "Pathologic organic aciduria has also been reported with long-term anticonvulsant therapy, suggesting biotin deficiency, but no mechanism leading to deficiency has yet been determined. "
05/01/1985 - "We conclude that plasma biotin concentration does not reflect biotin status in all cases and speculate that the biotin supplement currently recommended for pediatric patients (20 micrograms/day) may not be adequate therapy for biotin deficiency and might not even be adequate to maintain normal biotin status during TPN."
10/01/1982 - "The child with biotin deficiency grew normal hair following oral biotin therapy. "
05/01/2004 - "This case shows that in young children with unexplained seizures that do not respond well to classic anticonvulsant therapy, the possibility of biotin deficiency should always be considered. "

06/01/1995 - "Biotin deficiency complicating long-term total parenteral nutrition in an adult patient."
05/01/1985 - "Biotin deficiency associated with total parenteral nutrition is an emerging clinical problem; criteria for diagnosis and dosage for treatment are unclear. "
02/01/1983 - "Possible biotin deficiency in adults receiving long-term total parenteral nutrition."
11/01/1985 - "We report a case of biotin deficiency developed in a 25-yr-old man with Crohn's disease who had been on total parenteral nutrition for more than 9 months. "
04/01/1989 - "Biotin deficiency due to total parenteral nutrition alters serum fatty acid composition."

07/01/1981 - "Biotin deficiency as a complication of incomplete parenteral nutrition."
11/01/2010 - "Parenteral nutrition-associated biotin deficiency has not been reported since the vitamin has been routinely added to parenteral nutrition. "
09/01/1988 - "Abnormalities of fatty acid composition have been detected in the plasma of patients who developed frank biotin deficiency during parenteral nutrition. "
10/31/1987 - "[Zinc and biotin deficiency during prolonged parenteral nutrition in the infant]."
03/01/2000 - "Biotin deficiency in humans is extremely rare and is generally associated with prolonged parenteral nutrition, the consumption of large quantities of avidin, usually in the form of raw eggs, severe malnutrition and, inherited metabolic disorders. "

01/01/1969 - "[Hepatic regeneration after partial amputation of the liver in rats with biotin deficiency. "
01/01/1968 - "[Hepatic regeneration after partial amputation of the liver in rats with biotin deficiency. "
01/01/1968 - "[Liver regeneration after partial amputation of the liver in rats with biotin deficiency. "

06/11/1982 - "Biotin deficiency in an adult during home parenteral nutrition."
05/01/1984 - "Biotin deficiency in a patient with short bowel syndrome during home parenteral nutrition."
05/01/1984 - "Six months after receiving 2200 kcal/day of balanced home parenteral nutrition without biotin, she developed biotin deficiency with complete hair loss, eczematous dermatitis, waxy pallor, lethargy, and hypersthesias . "