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methyl 3- (4- (4,5- bis(4- (isopropyl(methyl)amino)phenyl)- 1H- imidazol- 2- yl)phenyl)acrylate

a multidrug resistance modulator; structure in first source

Also Known As:

FG 020326; FG-020326; FG020326

Networked: 3 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Carboxylic Acids: 973
  - Acyclic Acids
    - Acrylates: 212
      - methyl 3-(4-(4,5-bis(4-(isopropyl(methyl)amino)phenyl)-1H-imidazol-2-yl)phenyl)acrylate: 3
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Imidazoles: 150
      - methyl 3-(4-(4,5-bis(4-(isopropyl(methyl)amino)phenyl)-1H-imidazol-2-yl)phenyl)acrylate: 3

Experts

1.	Shi, Zhi: 2 articles (05/2012 - 08/2009)
2.	Zhang, Xu: 2 articles (05/2012 - 08/2009)
3.	Chen, Li-Ming: 1 article (05/2012)
4.	Fu, Li-Wu: 1 article (05/2012)
5.	Liang, Yong-Ju: 1 article (05/2012)
6.	Wang, Xiao-Kun: 1 article (05/2012)
7.	Wang, Xiu-Wen: 1 article (05/2012)
8.	Akiyama, Shin-ichi: 1 article (08/2009)
9.	Ambudkar, Suresh V: 1 article (08/2009)
10.	Ashby, Charles R: 1 article (08/2009)

Related Diseases

1.

Neoplasms (Cancer)

08/15/2009 - "Hence, FG020326 is characterized as a third generation MDR modulator that holds great promise for the treatment of cancer patients with ABCB1-mediated MDR."
05/09/2012 - "FG020326 sensitized multidrug resistant cancer cells to docetaxel-mediated apoptosis via enhancement of caspases activation."
07/01/2008 - "Folate-functionalized polymeric micelles for tumor targeted delivery of a potent multidrug-resistance modulator FG020326."
07/01/2008 - "To overcome multidrug resistance (MDR) existing in tumor chemotherapy, polymeric micelles encoded with folic acid on the micelle surface were prepared with the encapsulation of a potent MDR modulator, FG020326. "

Related Drugs and Biologics

1.	Caspases
2.	Micelles
3.	Folic Acid (Vitamin M)
4.	Docetaxel (Taxotere)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)