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AZD 1152-HQPA

active metabolite of AZD-1152

Also Known As:

barasertib-hQPA

Networked: 5 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Quinazolines: 402
      - AZD 1152-HQPA: 5

Experts

1.	Azzariti, Amalia: 1 article (01/2015)
2.	Cocco, Tiziana: 1 article (01/2015)
3.	Ferretta, Anna: 1 article (01/2015)
4.	Guida, Gabriella: 1 article (01/2015)
5.	Guida, Michele: 1 article (01/2015)
6.	Guida, Stefania: 1 article (01/2015)
7.	Iacobazzi, Rosa M: 1 article (01/2015)
8.	Maida, Immacolata: 1 article (01/2015)
9.	Porcelli, Letizia: 1 article (01/2015)
10.	Quatrale, Anna E: 1 article (01/2015)

Related Diseases

1.	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 09/01/2012 - "Barasertib (AZD1152) is a pro-drug that rapidly undergoes phosphatase-mediated cleavage in serum to release barasertib-hQPA, a selective Aurora B kinase inhibitor that has shown preliminary activity in clinical studies of patients with acute myeloid leukemia (AML). "
2.	Colorectal Neoplasms (Colorectal Cancer) 10/01/2012 - "Treatment with barasertib-hQPA produced anti-proliferative and cytotoxic effects across a panel of human colorectal cancer (CRC) cell lines in vitro. "
3.	Polyploidy 07/01/2013 - "Barasertib-HQPA induced polyploidy with a subsequent induction of sub-G1 phase apoptosis, indicating the M-phase specific cytotoxicity. "
4.	Necrosis 01/27/2015 - "Barasertib-HQPA induced the mitotic catastrophe, ultimately causing apoptosis and necrosis of cells, inhibited cell migration and strongly affected the glycolytic metabolism of cells inducing the release of lactate. "
5.	Gastrointestinal Neoplasms (Gastrointestinal Cancer) 10/01/2012 - "The activity of barasertib-hQPA, a selective inhibitor of Aurora-B kinase (ABK) was investigated in a range of preclinical models of gastrointestinal cancer. "

Related Drugs and Biologics

1.	Aurora Kinase B
2.	Prodrugs
3.	Phosphoric Monoester Hydrolases (Phosphatases)
4.	2- ((3- ((4- ((5- (2- ((3- fluorophenyl)amino)- 2- oxoethyl)- 1H- pyrazol- 3- yl)amino)quinazolin- 7- yl)oxy)propyl)(ethyl)amino)ethyl dihydrogen phosphate
5.	Member 1 Subfamily B ATP Binding Cassette Transporter
6.	Lactic Acid (Lactate)
7.	Proteins (Proteins, Gene)