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N- (1,3- benzodioxol- 5- ylmethyl)- 2,6- dichlorobenzamide

Cardioprotective Agent; a small-molecule activator of aldehyde dehydrogenase-2 that reduces ischemic damage to the heart

Also Known As:

Alda-1 cpd

Networked: 3 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Khan, Mushfiquddin: 1 article (01/2022)
2.	Kumar, Pavan: 1 article (01/2022)
3.	Qiao, Fei: 1 article (01/2022)
4.	Singh, Avtar K: 1 article (01/2022)
5.	Singh, Inderjit: 1 article (01/2022)
6.	Touhidul Islam, S M: 1 article (01/2022)
7.	Won, Jeseong: 1 article (01/2022)
8.	Belmont-Díaz, Javier A: 1 article (01/2015)
9.	Calleja-Castañeda, Luis F: 1 article (01/2015)
10.	Rodríguez-Zavala, José S: 1 article (01/2015)

Related Diseases

1.	Pain (Aches) 01/01/2022 - "In this study, we targeted the activity of mitochondrial enzyme aldehyde dehydrogenase 2 (ALDH2) to detoxify 4-HNE for accelerated functional recovery and improved pain-like behavior in a male mouse model of contusion SCI. N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide (Alda-1), a selective activator of ALDH2, was used as a therapeutic tool to suppress the 4-HNE load. "
2.	Contusions 01/01/2022 - "In this study, we targeted the activity of mitochondrial enzyme aldehyde dehydrogenase 2 (ALDH2) to detoxify 4-HNE for accelerated functional recovery and improved pain-like behavior in a male mouse model of contusion SCI. N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide (Alda-1), a selective activator of ALDH2, was used as a therapeutic tool to suppress the 4-HNE load. "
3.	Reperfusion Injury 01/01/2015 - "In this regard, N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide has been used to protect the heart against ischemia/reperfusion damage. "
4.	Necrosis 01/01/2023 - "We explored whether ALDH2 activated by N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide (Alda-1) could reduce the risk of ischemic random skin flap necrosis, and the possible mechanism of action. "
5.	Ischemia 01/01/2015 - "In this regard, N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide has been used to protect the heart against ischemia/reperfusion damage. "

Related Drugs and Biologics

1.	Enzymes
2.	Aldehyde Dehydrogenase