HOME PRODUCTS COMPANY CONTACT FAQ

Research Dictionary Pharma

Sign Up FREE or Login

RX 0047

a 20-mer phosphorothioate antisense oligonucleotide against HIF-1alpha

Also Known As:

RX-0047; RX0047

Networked: 3 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Nucleic Acids, Nucleotides, and Nucleosides: 1
- Nucleotides: 15763
  - Polynucleotides: 218
    - Oligonucleotides: 5145
      - RX 0047: 3

Experts

1.	Huang, Caixia: 1 article (07/2019)
2.	Huo, Jia: 1 article (07/2019)
3.	Tan, Wenlong: 1 article (07/2019)
4.	Yang, Ronghua: 1 article (07/2019)
5.	Zheng, Jing: 1 article (07/2019)
6.	Zhu, Cong: 1 article (07/2019)
7.	Ahn, Chang-Ho: 1 article (01/2016)
8.	Cheng, Xinwei: 1 article (01/2016)
9.	Kim, Deog Joong: 1 article (01/2016)
10.	Lee, Robert J: 1 article (01/2016)

Related Diseases

1.	Neoplasms (Cancer) 06/01/2008 - "This study was performed to determine the antitumoral efficacy of an antisense HIF-1alpha inhibitor, RX-0047 on different human cancer cell lines (MDA-MB 231, HME50-T, PC-3, Panc-1 and A549) in vitro. " 06/01/2008 - "Finally, RX-0047 (30 mg/kg) inhibited the formation of human lung metastasis in xenograft mouse models and reduced tumor size in flank models." 01/01/2016 - "Lipid-albumin nanoparticles (LAN) were synthesized for delivery of RX-0047, an antisense oligonucleotide (ASO) against the hypoxia inducible factor-1 alpha (HIF-1α) to solid tumor. "
2.	Hypoxia (Hypoxemia) 07/24/2019 - "The siRNA was designed to contain hypoxia-inducible factor (HIF)-1α against RX-0047, which can induce significant downregulation of HIF-1α protein. " 01/01/2016 - "Lipid-albumin nanoparticles (LAN) were synthesized for delivery of RX-0047, an antisense oligonucleotide (ASO) against the hypoxia inducible factor-1 alpha (HIF-1α) to solid tumor. "
3.	Neoplasm Metastasis (Metastasis) 06/01/2008 - "Finally, RX-0047 (30 mg/kg) inhibited the formation of human lung metastasis in xenograft mouse models and reduced tumor size in flank models."

Related Drugs and Biologics

1.	Small Interfering RNA (siRNA)
2.	Antisense Oligonucleotides
3.	Proteins (Proteins, Gene)
4.	Lipids
5.	Albumins