|1.||Lyons, John F: 3 articles (01/2011 - 02/2009)|
|2.||Lewis, E Jonathan: 3 articles (04/2010 - 08/2008)|
|3.||Dolman, M Emmy M: 2 articles (11/2015 - 01/2014)|
|4.||Molenaar, Jan J: 2 articles (11/2015 - 01/2014)|
|5.||den Hartog, Ilona J M: 2 articles (11/2015 - 01/2014)|
|6.||Sparidans, Rolf W: 2 articles (11/2015 - 01/2014)|
|7.||Squires, M: 2 articles (12/2014 - 04/2010)|
|8.||Thompson, Neil T: 2 articles (04/2010 - 02/2009)|
|9.||Squires, Matthew S: 2 articles (04/2010 - 02/2009)|
|10.||Smith, Donna-Michelle: 2 articles (02/2009 - 08/2008)|
11/15/2015 - "The improved efficacy of AT7519 observed in Th-MYCN mice correlated with higher tumor exposure to the drug. "
04/22/2010 - "In this study, we investigate the preclinical activity of a novel small-molecule multi-CDK inhibitor, AT7519, in MM. We show the anti-MM activity of AT7519 displaying potent cytotoxicity and apoptosis; associated with in vivo tumor growth inhibition and prolonged survival. "
02/01/2009 - "Studies described here formed the biological rationale for investigating the potential therapeutic benefit of AT7519 in cancer patients."
08/28/2008 - "Optimisation of cellular activity and characterization of pharmacokinetic properties led to the identification of 33 (AT7519), which is currently being evaluated in clinical trials for the treatment of human cancers."
12/09/2014 - "At this dose level, plasma AT7519 concentrations were above the biologically active concentrations, and preliminary anti-cancer activity was observed in patients. "
|2.||B-Cell Leukemia (Leukemia, B Cell)
01/01/2011 - "Administration of AT7519 dramatically enhanced the resolution of allergic pleurisy via direct induction of eosinophil apoptosis without detriment to macrophage clearance of these cells. "
01/01/2011 - "Our data show that AT7519 induces human eosinophil apoptosis and enhances the resolution of a murine model of allergic pleurisy by inducing caspase-dependent eosinophil apoptosis and enhancing macrophage ingestion of apoptotic eosinophils. "
01/01/2011 - "Therapeutic administration of AT7519 in eosinophil-dominant allergic inflammation was investigated using an established ovalbumin-sensitised mouse model of allergic pleurisy. "
11/15/2015 - "This study strongly suggests that AT7519 is a promising drug for the treatment of high-risk neuroblastoma patients with MYCN amplification. "
11/15/2015 - "AT7519 killed MYCN-amplified neuroblastoma cell lines more potently than MYCN single copy cell lines with a median LC50 value of 1.7 compared to 8.1 μmol/L (P = 0.0053) and a significantly stronger induction of apoptosis. "
11/15/2015 - "Preclinical studies in female NMRI homozygous (nu/nu) mice with neuroblastoma patient-derived MYCN-amplified AMC711T xenografts revealed dose-dependent growth inhibition, which correlated with intratumoral AT7519 levels. "
01/01/2014 - "Finally, the assay was successfully used to determine plasma pharmacokinetics after intraperitoneal administration of AT7519 in mice with neuroblastoma xenografts. "
11/15/2015 - "Cyclin-Dependent Kinase Inhibitor AT7519 as a Potential Drug for MYCN-Dependent Neuroblastoma."
04/01/2010 - "Here, we describe the characterization of AT7519 in leukemia cell lines, and compare and contrast the response in cell lines derived from solid tumors. "
04/01/2010 - "AT7519, a cyclin-dependent kinase inhibitor, exerts its effects by transcriptional inhibition in leukemia cell lines and patient samples."
07/01/2014 - "We hypothesized that targeting the intracellular protein myeloid cell leukemia 1 (Mcl-1) by a cyclin-dependent kinase inhibitor (AT7519) or a flavone (wogonin) would accelerate neutrophil apoptosis and resolution of established inflammation, but without detriment to bacterial clearance. "
|4.||ATP-Binding Cassette Transporters (ABC Transporters)
|5.||RNA Polymerase II (RNA Polymerase B)
|7.||N- (5- (((5- (1,1- dimethylethyl)- 2- oxazolyl)methyl)thio)- 2- thiazolyl)- 4- piperidinecarboxamide
|8.||glycogen synthase kinase 3 beta
|9.||multidrug resistance-associated protein 1
|10.||benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone
|2.||Heterologous Transplantation (Xenotransplantation)