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1,2- bis(methylsulfonyl)- 1- (2- chloroethyl)hydrazine
a chloroethylating agent that alkylates and cross-links DNA; structure in first source
Also Known As:
90CE compound
Networked:
1
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Organic Chemicals: 133
Amides: 2428
Sulfonamides: 2809
1,2-bis(methylsulfonyl)-1-(2-chloroethyl)hydrazine: 1
Hydrazines: 379
1,2-bis(methylsulfonyl)-1-(2-chloroethyl)hydrazine: 1
Sulfur Compounds: 278
Sulfones: 534
Sulfonamides: 2809
1,2-bis(methylsulfonyl)-1-(2-chloroethyl)hydrazine: 1
Experts
1.
Penketh, Philip G
: 1 article (06/2005)
2.
Rockwell, Sara
: 1 article (06/2005)
3.
Sartorelli, Alan C
: 1 article (06/2005)
4.
Seow, Helen A
: 1 article (06/2005)
5.
Shyam, Krishnamurthy
: 1 article (06/2005)
Related Diseases
1.
Neoplasms (Cancer)
06/28/2005 - "
To target malignant cells residing in hypoxic regions of solid tumors, we have designed and synthesized prodrugs generating the cytotoxic alkylating species 1,2-bis(methylsulfonyl)-1-(2-chloroethyl)hydrazine (90CE) after bioreductive activation.
"
Related Drugs and Biologics
1.
Prodrugs