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gamendazole

Spermatogenesis Blocking Agents; structure in first source

Also Known As:

trans-3-(1-benzyl-6-(trifluoromethyl)-1H-indazol-3-yl)acrylic acid

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Pyrazoles: 61
      - Indazoles: 179
        gamendazole: 3
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Indazoles: 179
      - gamendazole: 3

Experts

1.	Chakrasali, Ramappa: 2 articles (06/2008 - 06/2008)
2.	Georg, Gunda I: 2 articles (06/2008 - 06/2008)
3.	Jakkaraj, Sudhakar R: 2 articles (06/2008 - 06/2008)
4.	Tash, Joseph S: 2 articles (06/2008 - 06/2008)
5.	Attardi, Barbara: 1 article (06/2008)
6.	Blagg, Brian S J: 1 article (06/2008)
7.	Hadden, M Kyle: 1 article (06/2008)
8.	Heckert, Leslie L: 1 article (06/2008)
9.	Hild, Sheri A: 1 article (06/2008)
10.	Hornbaker, Kaori: 1 article (06/2008)

Related Diseases

1.	Infertility (Sterility) 06/01/2008 - "An infertility rate of 100% was achieved in seven out of seven proven-fertile male rats 3 wk after a single oral dose of 6 mg/kg of gamendazole. " 06/01/2008 - "A current model for gamendazole action posits that this pathway links interaction with HSP90AB1 and EEF1A1 to the loss of spermatids and resulting infertility." 06/01/2008 - "In the animals that showed reversible infertility, a transient increase in circulating FSH levels coincided with an initial decline in inhibin B levels after administration of gamendazole, but no other significant changes in circulating reproductive hormones were observed. "
2.	Ovarian Neoplasms (Ovarian Cancer) 06/01/2008 - "Both HSP90AB1 (previously known as HSP90beta [heat shock 90-kDa protein 1, beta]) and EEF1A1 (previously known as eEF1A [eukaryotic translation elongation factor 1 alpha 1]) were identified as binding targets by biotinylated gamendazole (BT-GMZ) affinity purification from testis, Sertoli cells, and ID8 ovarian cancer cells; identification was confirmed by matrix-assisted laser desorption/ionization-time of flight mass spectrometry and Western blot analysis. "
3.	Polycystic Kidney Diseases (Polycystic Kidney Disease) 12/01/2022 - "H2-gamendazole: a new therapeutic lead for the treatment of polycystic kidney disease."

Related Drugs and Biologics

1.	Peptide Elongation Factor 1 (EF-1)
2.	Proteins (Proteins, Gene)
3.	Hormones (Hormone)
4.	inhibin B

Related Therapies and Procedures

1.	Lasers (Laser)