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CGS 7184

a potassium channel opener

Also Known As:

CGS7184; ethyl-1-(((4-chlorophenyl)amino)oxo)-2-hydroxy-6-trifluoromethyl-1H-indole-3-carboxylate

Networked: 2 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Indoles: 200
      - CGS 7184: 2

Experts

1.	Augustynek, Bartłomiej: 1 article (01/2018)
2.	Koprowski, Piotr: 1 article (01/2018)
3.	Kulawiak, Bogusz: 1 article (01/2018)
4.	Kunz, Wolfram S: 1 article (01/2018)
5.	Rotko, Daria: 1 article (01/2018)
6.	Szewczyk, Adam: 1 article (01/2018)
7.	Debska-Vielhaber, G: 1 article (12/2009)
8.	Godlewski, M M: 1 article (12/2009)
9.	Kicinska, A: 1 article (12/2009)
10.	Kulawiak, B: 1 article (12/2009)

Related Diseases

1.	Glioma (Gliomas) 12/01/2009 - "In the micromolar concentration range CGS7181 and CGS7184 induced glioma cell death. " 12/01/2009 - "In the present study we investigated whether BK(Ca)-channel openers, such as CGS7181 (ethyl 2-hydroxy-1-[[(4-methylphenyl)amino]oxo]-6-trifluoromethyl-1H-indole-3-carboxylate) and CGS7184 (ethyl 1-[[(4-chlorophenyl)amino]oxo]-2-hydroxy-6-trifluoromethyl-1H-indole-3-carboxylate), affect the functioning of LN229 glioma cell mitochondria in situ. " 12/01/2009 - "In conclusion, our results show that CGS7181 and CGS7184 induce glioma cell death by increasing the cytosolic calcium concentration followed by activation of calpains."
2.	Astrocytoma (Pilocytic Astrocytoma) 01/25/2018 - "We showed that CGS7184 activated the mitochondrial BKCa (mitoBKCa) channel in single-channel recordings performed on astrocytoma mitoplasts. "

Related Drugs and Biologics

1.	ethyl 2- hydroxy- 1- (((4- methylphenyl)amino)oxo)- 6- trifluoromethyl- 1H- indole- 3- carboxylate
2.	indole
3.	Calcium