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N-hydroxy-valdecoxib

an active metabolite of valdecoxib; structure in first source

Also Known As:

N-hydroxyvaldecoxib

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Isoxazoles: 155
      - N-hydroxy-valdecoxib: 1
Organic Chemicals: 133
- Amides: 2428
  - Sulfonamides: 2809
    - N-hydroxy-valdecoxib: 1
- Sulfur Compounds: 278
  - Sulfones: 534
    - Sulfonamides: 2809
      - N-hydroxy-valdecoxib: 1

Experts

1.	Bittner, Florian: 1 article (11/2010)
2.	Clement, Bernd: 1 article (11/2010)
3.	Erdélyi, Péter: 1 article (11/2010)
4.	Fischer, János: 1 article (11/2010)
5.	Grünewald, Sanja: 1 article (11/2010)
6.	Havemeyer, Antje: 1 article (11/2010)
7.	Mendel, Ralf: 1 article (11/2010)
8.	Wahl, Bettina: 1 article (11/2010)

Related Diseases

1.	Pain (Aches) 11/01/2010 - "In continuation of our drug metabolism investigations (Havemeyer et al., 2006; Gruenewald et al., 2008), we present data from reconstituted enzyme systems with recombinant human and native porcine enzymes showing the reduction of N-hydroxy-sulfonamides (sulfohydroxamic acids) to sulfonamides: the N-hydroxy-sulfonamide N-hydroxy-valdecoxib (N-hydroxy-4-[5-methyl-3-phenyl-4-isoxazolyl]-benzenesulfonamide) represents a novel cyclooxygenase (COX)-2 inhibitor and is therefore a drug candidate in the treatment of diseases associated with rheumatic inflammation, pain, and fever. "
2.	Inflammation (Inflammations) 11/01/2010 - "In continuation of our drug metabolism investigations (Havemeyer et al., 2006; Gruenewald et al., 2008), we present data from reconstituted enzyme systems with recombinant human and native porcine enzymes showing the reduction of N-hydroxy-sulfonamides (sulfohydroxamic acids) to sulfonamides: the N-hydroxy-sulfonamide N-hydroxy-valdecoxib (N-hydroxy-4-[5-methyl-3-phenyl-4-isoxazolyl]-benzenesulfonamide) represents a novel cyclooxygenase (COX)-2 inhibitor and is therefore a drug candidate in the treatment of diseases associated with rheumatic inflammation, pain, and fever. "
3.	Fever (Fevers) 11/01/2010 - "In continuation of our drug metabolism investigations (Havemeyer et al., 2006; Gruenewald et al., 2008), we present data from reconstituted enzyme systems with recombinant human and native porcine enzymes showing the reduction of N-hydroxy-sulfonamides (sulfohydroxamic acids) to sulfonamides: the N-hydroxy-sulfonamide N-hydroxy-valdecoxib (N-hydroxy-4-[5-methyl-3-phenyl-4-isoxazolyl]-benzenesulfonamide) represents a novel cyclooxygenase (COX)-2 inhibitor and is therefore a drug candidate in the treatment of diseases associated with rheumatic inflammation, pain, and fever. "

Related Drugs and Biologics

1.	Sulfonamides
2.	Prostaglandin-Endoperoxide Synthases (Cyclooxygenase)
3.	Enzymes
4.	Acids
5.	Benzenesulfonamides