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STF 62247

has antineoplastic activity; structure in first source

Also Known As:

STF-62247; STF62247

Networked: 6 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Thiazoles: 392
      - STF 62247: 6
  - Pyridines: 88
    - STF 62247: 6
Organic Chemicals: 133
- Sulfur Compounds: 278
  - Thiazoles: 392
    - STF 62247: 6

Experts

1.	Turcotte, Sandra: 2 articles (01/2022 - 07/2008)
2.	Chan, Denise A: 2 articles (10/2008 - 07/2008)
3.	Giaccia, Amato J: 2 articles (10/2008 - 07/2008)
4.	Barnett, David A: 1 article (01/2022)
5.	Cuperlovic-Culf, Miroslava: 1 article (01/2022)
6.	Johnson, Mathieu: 1 article (01/2022)
7.	Joy, Andrew P: 1 article (01/2022)
8.	Nowlan, Sarah: 1 article (01/2022)
9.	Sahin, Gülsüm: 1 article (01/2022)
10.	Touaibia, Mohamed: 1 article (01/2022)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2022 - "We previously identified a small molecule, STF-62247, which target VHL-deficient renal tumors by affecting late-stages of autophagy and lysosomal signaling. " 07/08/2008 - "STF-62247 induces cytotoxicity and reduces tumor growth of VHL-deficient RCC cells compared to genetically matched cells with wild-type VHL. " 08/01/2020 - "Then, the exposed C-TFG micelle can sensitively respond to oxaliplatin-induced autophagy and release a powerful autophagy inducer STF-62247, which precisely transforms autophagy to "overactivated" condition, leading tumor cells to autophagic death and enhance subsequent tumor antigen processing of the dying cells. "
2.	Renal Cell Carcinoma (Grawitz Tumor) 06/12/2018 - "STF-62247 induces autophagy and selectively kills renal cell carcinoma without apoptotic cell death. " 10/01/2008 - "Recently, we identified a compound, STF-62247, that functions in a synthetic lethal manner to the loss of VHL, a mutation found in the majority of renal cell carcinomas."
3.	Glioblastoma (Glioblastoma Multiforme) 01/01/2018 - "Loperamide, pimozide, and STF-62247 trigger autophagy-dependent cell death in glioblastoma cells."

Related Drugs and Biologics

1.	Pimozide (Orap)
2.	Micelles
3.	Loperamide (Imodium)
4.	Neoplasm Antigens (Tumor Antigens)
5.	Oxaliplatin (Eloxatin)