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KD 5170

a histone deacetylase inhibitor; structure in first source

Also Known As:

KD-5170; KD5170

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyridines: 88
    - KD 5170: 3
Organic Chemicals: 133
- Amides: 2428
  - Sulfonamides: 2809
    - KD 5170: 3
- Sulfur Compounds: 278
  - Sulfones: 534
    - Sulfonamides: 2809
      - KD 5170: 3

Experts

1.	Hager, Jeffrey H: 3 articles (12/2008 - 05/2008)
2.	Hassig, Christian A: 3 articles (12/2008 - 05/2008)
3.	Payne, Joseph E: 3 articles (12/2008 - 05/2008)
4.	Smith, Nicholas D: 3 articles (12/2008 - 05/2008)
5.	Annable, Tami: 2 articles (12/2008 - 05/2008)
6.	Bonnefous, Céline: 2 articles (12/2008 - 05/2008)
7.	Guo, Xin: 2 articles (12/2008 - 05/2008)
8.	Hoffman, Timothy Z: 2 articles (12/2008 - 05/2008)
9.	Malecha, James W: 2 articles (12/2008 - 05/2008)
10.	Nguyen, Phan-Manh: 2 articles (12/2008 - 05/2008)

Related Diseases

1.	Neoplasms (Cancer) 12/01/2008 - "KD5170 exhibits robust and sustained histone H3 hyperacetylation in HCT-116 xenograft tumors following single oral or i.v. dose and inhibition of tumor growth following chronic dosing." 12/01/2008 - "We report the identification of KD5170, a potent mercaptoketone-based Class I and II-histone deacetylase inhibitor that demonstrates broad spectrum cytotoxic activity against a range of human tumor-derived cell lines. " 06/01/2008 - "Histone acetylation was increased in spleen and tumor tissues of animals treated with KD5170. "
2.	Prostatic Neoplasms (Prostate Cancer) 05/01/2008 - "In addition, a significant increase in antitumor activity and time to end-point occurred when KD5170 was combined with docetaxel in xenografts of the PC-3 prostate cancer cell line. "

Related Drugs and Biologics

1.	Histones (Histone)
2.	Histone Deacetylase Inhibitors
3.	Docetaxel (Taxotere)