3,5- diethoxycarbonyl- 1,4- dihydrocollidine

Both 5-diethoxycarbonyl-1,4-dihydrocollidine (DDC) and carbon tetrachloride (CCl(4)) cooperate with MYC to greatly accelerate the onset of liver cancer in an adult host to less than 7 days versus a mean latency of onset of over 35 weeks for MYC alone

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Networked: 100 relevant articles (2 outcomes, 9 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Trauner, Michael: 5 articles (01/2020 - 08/2007)
2.	Denk, Helmut: 5 articles (01/2018 - 08/2007)
3.	Popov, Yury V: 4 articles (01/2019 - 01/2017)
4.	Fickert, Peter: 4 articles (02/2018 - 08/2007)
5.	Zatloukal, Kurt: 4 articles (01/2018 - 08/2007)
6.	Coll, Mar: 3 articles (01/2022 - 01/2016)
7.	Sancho-Bru, Pau: 3 articles (01/2022 - 01/2016)
8.	Robson, Simon C: 3 articles (01/2019 - 11/2017)
9.	Rothweiler, Sonja: 3 articles (01/2019 - 11/2017)
10.	Vaid, Kahini A: 3 articles (01/2018 - 01/2017)

Related Diseases

1.	Fibrosis (Cirrhosis) 01/01/2017 - "Therapeutic efficacy in biliary fibrosis was tested in BALB/c.Mdr2-/- and 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC)-fed mice. " 12/04/2023 - "This study aimed to explore the mechanism of MT on hepatic BA synthesis, liver injury, and fibrosis in 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC)-fed and Mdr2-/- mice. " 08/11/2021 - "Therefore, we investigated the effects of bvPLA2 on cholestatic liver injury and fibrosis in a murine model of 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC) diet feeding. " 09/01/2019 - "Liver injury in mice was induced with 3,5-diethoxycarbonyl-1,4-dihydrocollidine, and HPC expansion and fibrosis were assessed. " 01/01/2019 - "Global CD39 null (Cd39-/-), wild-type (WT), LysMCreCd39fl/fl, and Cd39fl/fl control mice were exposed to 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC) to induce biliary fibrosis. "
2.	Porphyrias (Porphyria) 04/15/1979 - "Studies on the mechanism of experimental porphyria produced by 3,5-diethoxycarbonyl-1,4-dihydrocollidine. " 05/01/1997 - "These were tested either alone or in conjunction with 3,5-diethoxycarbonyl-1,4-dihydrocollidine (latent porphyria model) in chick embryos and in mice. " 07/01/1973 - "4. Compound SKF 525-A (2-diethylaminoethyl 3,3-diphenylpropylacetate) when given before 3,5-diethoxycarbonyl-1,4-dihydrocollidine prevents the appearance of porphyria in the rat and also largely prevents the decrease of chelatase activity. " 07/15/2002 - "3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC)-induced porphyria, and in a model of non-acute porphyria, i.e. " 01/01/1980 - "Studies on the mechanism of experimental porphyria and ferrochelatase inhibition produced by 3,5-diethoxycarbonyl-1,4-dihydrocollidine."
3.	Liver Cirrhosis (Hepatic Cirrhosis) 12/01/2018 - "In this study, we demonstrate that loss of PHD1 (PHD1-/-) attenuates the development of liver fibrosis in mice subjected to chronic bile duct injury, induced by 3,5-diethoxycarbonyl-1,4-dihydrocollidine. " 01/10/2024 - "Twenty-four C57BL/6 mice were used to induce liver fibrosis by feeding a diet that contained 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC). " 01/01/2020 - "For the mouse model of acute-on-chronic liver injury, we used 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC, 0.05% w/w) diet for 8 weeks to establish cholestatic liver fibrosis. " 12/01/2014 - "CCl4 or 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC) 0.1% (wt/wt) Purina 5015 Chow (LabDiet, St. Louis, MO) was fed for 3 weeks to induce liver fibrosis. " 01/01/2021 - "In chronically injured livers induced by a 0.1% 3,5-diethoxycarbonyl-1,4-dihydrocollidine diet or bile duct ligation surgery, HPCs were dramatically activated, as indicated by their enhanced expression of Brg1 and a subset of stem cell markers; however, Brg1 ablation in HPCs strongly suppressed HPC expansion and liver fibrosis. "
4.	Cholangitis 01/01/2021 - "Homologous mutation knock-in mice developed similar IFN-γ impairment in T cells and were more prone to develop severe cholangitis when exposed to 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC) diet. " 08/25/2015 - "Feeding 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC) to mice is a well-established animal model to study cholangitis and biliary fibrosis. " 01/01/2021 - "To this end, we generated a mouse model which combines cholangiocyte-specific expression of KrasG12D with 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC) diet-induced inflammation to mimic iCCA development in patients with cholangitis. " 01/01/2019 - "Diet containing 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC) was fed to Nrf2-KO mice (Nrf2-/-), mice with liver-specific hyperactivated Nrf2 (HKeap1-/-) and wild-type (WT) littermates to induce cholangitis, liver fibrosis, and oval cell expansion. " 01/01/2023 - "hP-MSCs were injected via the tail vein into Mdr2-/-, bile duct ligation (BDL), and 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC) mouse models or co-cultured with organoids to confirm their therapeutic effect on biliary cholangitis. "
5.	Fatty Liver 01/01/2014 - "In this study we have analyzed three different mouse strains, A/J, C57BL/6J, and PWD/PhJ, that show different degrees of steatohepatitis when administered a 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC) containing diet. " 01/01/2018 - "Chronic intoxication of mice with the porphyrinogenic compound 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC) leads to morphological and metabolic changes closely resembling steatohepatitis, a severe form of metabolic liver disease in humans. "

Related Drugs and Biologics

1.	Carbon Tetrachloride (Tetrachloromethane)
2.	alpha- cyano- (3,4- dihydroxy)- N- benzylcinnamide
3.	Ferrochelatase (Heme Synthetase)
4.	Adrenergic Agents (Adrenergic Drugs)
5.	Tamoxifen
6.	Griseofulvin (Grifulvin V)
7.	Xenobiotics
8.	Thioacetamide (Thioacetamid)
9.	Heme (Haem)
10.	Aminolevulinic Acid (Levulan)

Related Therapies and Procedures

1.	Ligation
2.	Intraperitoneal Injections
3.	Injections
4.	Hepatectomy