|1.||Potter, Barry V L: 3 articles (10/2015 - 02/2003)|
|2.||Leese, Mathew P: 2 articles (10/2015 - 02/2003)|
|3.||Reed, M J: 2 articles (02/2004 - 02/2003)|
|4.||Potter, B V L: 2 articles (02/2004 - 02/2003)|
|5.||Purohit, A: 2 articles (02/2004 - 02/2003)|
|6.||Leese, M P: 2 articles (02/2004 - 02/2003)|
|7.||Newman, S P: 2 articles (02/2004 - 02/2003)|
|8.||Reed, Michael J: 2 articles (02/2003 - 02/2003)|
|9.||Purohit, Atul: 2 articles (02/2003 - 02/2003)|
|10.||Ferrer-Torres, Daysha: 1 article (10/2015)|
06/01/2011 - "2-Methoxyoestradiol, a metabolite of COMT, increases human trophoblast invasiveness in vitro under hypoxic conditions, providing further support that decreased COMT expression may have a role in preeclampsia. "
05/01/2013 - "Deficiencies in placental catechol-O-methyltransferase (COMT) and circulating 2-methoxyoestradiol (2-ME) have been shown to be related to early onset preeclampsia. "
05/01/2013 - "2-methoxyoestradiol levels and placental catechol-O-methyltransferase expression in patients with late-onset preeclampsia."
06/19/2008 - "Deficiency in catechol-O-methyltransferase and 2-methoxyoestradiol is associated with pre-eclampsia."
09/01/2015 - "It was reported that pregnant mice deficient in catechol-O-methyltransferase (COMT) activity show a preeclampsia-like phenotype due to a deficiency or absence of 2-methoxyoestradiol (2-ME), a natural metabolite of estradiol that is elevated during the third trimester of normal human pregnancy. "
06/01/2007 - "Herein, we demonstrate that 2-methoxyoestradiol (2ME), but not 17beta-oestradiol, induces apoptosis in cancer cell lines and primary cultured tumours of endometrial origin. "
02/23/2004 - "2-Methoxyoestradiol (2-MeOE2) is an endogenous oestrogen metabolite that inhibits the proliferation of cancer cells in vitro, and it is also antiangiogenic. "
04/01/2002 - "Thus, PUFAs, thalidomide and 2-methoxyoestradiol or their derivatives may offer a new radical approach to the treatment of cancer."
04/01/2002 - "2-methoxyoestradiol and polyunsaturated fatty acids (PUFAs) inhibit SODs and cause an increase of O2(-*) in tumor cells leading to their death. "
10/20/2015 - "Targeted NF1 cancer therapeutics with multiple modes of action: small molecule hormone-like agents resembling the natural anticancer metabolite, 2-methoxyoestradiol."
|3.||Breast Neoplasms (Breast Cancer)
05/20/2007 - "2-methoxyoestradiol is a potent antiproliferative and antiangiogenic metabolite, and is currently tested in patients with refractory metastatic breast cancer. "
02/01/2003 - "The endogenous oestrogen metabolite, 2-methoxyoestradiol (2-MeOE2) inhibits the growth of breast cancer cells and is also a potent anti-angiogenic agent. "
02/01/2003 - "The human endogenous metabolite 2-methoxyoestradiol (2-MeOE2) has been shown to inhibit the proliferation of breast cancer cells. "
02/01/2003 - "There is currently considerable interest in the use of the endogenous oestrogen metabolite, 2-methoxyoestradiol (2-MeOE2) for the treatment and prevention of breast cancer. "
|1.||Catechol O-Methyltransferase (Methyltransferase, Catechol)
|7.||Unsaturated Fatty Acids (Polyunsaturated Fatty Acids)