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3- ((4- (4- (acridin- 9- ylamino)phenylthio)phenyl)(3- hydroxypropyl)amino)propan- 1- ol

has antineoplastic activity; structure in first source

Also Known As:

CK 0403; CK-0403; CK0403

Networked: 3 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 3-Ring Heterocyclic Compounds
    - Acridines: 325
      - 3-((4-(4-(acridin-9-ylamino)phenylthio)phenyl)(3-hydroxypropyl)amino)propan-1-ol: 3
Inorganic Chemicals: 9
- Electrolytes: 16106
  - Ions: 7857
    - Anions: 3501
      - Sulfides: 1062
        3-((4-(4-(acridin-9-ylamino)phenylthio)phenyl)(3-hydroxypropyl)amino)propan-1-ol: 3
- Sulfur Compounds: 278
  - Hydrogen Sulfide: 2764
    - Sulfides: 1062
      - 3-((4-(4-(acridin-9-ylamino)phenylthio)phenyl)(3-hydroxypropyl)amino)propan-1-ol: 3
Organic Chemicals: 133
- Sulfur Compounds: 278
  - Sulfides: 1062
    - 3-((4-(4-(acridin-9-ylamino)phenylthio)phenyl)(3-hydroxypropyl)amino)propan-1-ol: 3

Experts

1.	Kwon, Chul-Hoon: 2 articles (01/2016 - 04/2008)
2.	Chen, Kuen-Yuan: 1 article (01/2016)
3.	Chen, Kun-Ming: 1 article (01/2016)
4.	Sun, Yuan-Wan: 1 article (01/2016)
5.	Kang, Hyerim: 1 article (04/2008)
6.	Park, Sang-ki: 1 article (04/2008)

Related Diseases

1.	Breast Neoplasms (Breast Cancer) 01/01/2016 - "In order to identify novel chemotherapeutic agents with enhanced potency, the present study explored the potential of CK0403 in the treatment of breast cancer. " 01/01/2016 - "CK0403, a 9‑aminoacridine, is a potent anti‑cancer agent in human breast cancer cells." 01/01/2016 - "The results showed that CK0403 exerted more potent growth inhibitory activity than CK0402 in all of the breast cancer cell lines except MCF‑7. " 01/01/2016 - "First, the growth inhibitory activity of CK0403 in the breast cancer cell lines MCF‑7, MDA‑MB‑231, BT474 and SKBR‑3, as well as in the non‑cancerous MCF‑10A cell line, was examined using a sulforhodamine B assay. " 12/26/2022 - "CK0403 is reported in breast cancer treatment and is more potent than CK0402 against estrogen receptor-negative HER2. "
2.	Neoplasms (Cancer) 04/01/2008 - "9-anilinoacridine contains a tricyclic and planar aromatic structure that enables DNA intercalation and inhibition of topoisomerase II. Two recently developed sulfide derivatives of 9-anilinoacridines, 2-({4-[4-(acridin-9-ylamino)phenylthio]phenyl}(2-hydroxyethyl)amino)ethan-1-ol (CK0402) and 3-({4-[4-(acridin-9-ylamino)phenylthio]phenyl}(3-hydroxypropyl)amino)propan-1-ol (CK0403), displayed potent cytotoxic activity in multiple cancer cell lines. "

Related Drugs and Biologics

1.	2- ((4- (4- (acridin- 9- ylamino)phenylthio)phenyl)(2- hydroxyethyl)amino)ethan- 1- ol
2.	Estrogen Receptors
3.	Sulfides (Thioethers)
4.	Type II DNA Topoisomerases (Topoisomerase II)
5.	DNA (Deoxyribonucleic Acid)
6.	9-anilinoacridine
7.	lissamine rhodamine B (sulforhodamine B)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)