|1.||Treston, Anthony M: 2 articles (04/2011 - 06/2008)|
|2.||Fogler, William E: 2 articles (06/2008 - 01/2008)|
|3.||Cross-Knorr, Sam: 1 article (01/2014)|
|4.||Chin, Eugene: 1 article (01/2014)|
|5.||Yousuf, Saad: 1 article (01/2014)|
|6.||Moen, Erika L: 1 article (01/2014)|
|7.||Al-Mulla, Fahd: 1 article (01/2014)|
|8.||Duan, MeiLi: 1 article (01/2014)|
|9.||Bonavida, Benjamin: 1 article (01/2014)|
|10.||LaValle, Theresa: 1 article (01/2014)|
01/01/2008 - "In vivo, treatment with ENMD-1198 led to a significant reduction in tumor growth, tumor vascularization, and numbers of proliferating tumor cells (P < 0.05 for all). "
04/01/2011 - "This first-in-human phase I study evaluated the tolerability, pharmacokinetics and preliminary evidence of activity of ENMD-1198 in advanced cancer patients. "
06/01/2008 - "ENMD-1198 was selected as the lead molecule in this analogue series and is currently in a phase I clinical trial in patients with refractory solid tumors."
01/01/2008 - "The novel microtubule destabilizing agent ENMD-1198 is suitable for inhibiting HIF-1alpha and STAT3 in human HCC cells and leads to reduced tumor growth and vascularization in vivo. "
01/01/2008 - "The growth-inhibitory effects of ENMD-1198 (200 mg/kg/day) were determined in a subcutaneous tumor model (HUH-7). "
|2.||Lewis Lung Carcinoma
|3.||Prostatic Neoplasms (Prostate Cancer)
|5.||Breast Neoplasms (Breast Cancer)
01/01/2014 - "The treatment of DU145 prostate, but not PC3 prostate or MDA-231 breast, cancer cell lines with ENMD-1198 or MKC-1 dramatically increased expression of RKIP. "
05/01/2011 - "We confirmed the in vitro data with a series of in vivo experiments showing the beneficial effects of ENMD-1198 and ENMD-1198-based combination treatments of metastatic breast cancer in bone both on tumor progression and on survival with long-term ENMD-1198 treatment. "
05/01/2011 - "2-methoxyestradiol analogue ENMD-1198 reduces breast cancer-induced osteolysis and tumor burden both in vitro and in vivo."
|3.||Intercellular Signaling Peptides and Proteins (Growth Factors)
|6.||2- methoxyestradiol- 3,17- O,O- bis(sulfamate)