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irilone

structure in first source

Networked: 2 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrans: 130
    - Benzopyrans: 195
      - Chromones: 159
        Flavonoids: 9773
        Isoflavones: 2663
        irilone: 2
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzopyrans: 195
      - Chromones: 159
        Flavonoids: 9773
        Isoflavones: 2663
        irilone: 2

Experts

1.	Austin, Julia R: 2 articles (12/2021 - 01/2018)
2.	Burdette, Joanna E: 2 articles (12/2021 - 01/2018)
3.	Murphy, Brian T: 2 articles (12/2021 - 01/2018)
4.	Lantvit, Daniel D: 1 article (12/2021)
5.	Li, Kailiang: 1 article (12/2021)
6.	Rivera Rodríguez, Rocío: 1 article (12/2021)
7.	Dean, Matthew: 1 article (01/2018)
8.	Lee, Jung-Ho: 1 article (01/2018)

Related Diseases

1.	Breast Neoplasms (Breast Cancer) 12/24/2021 - "In this study, irilone enhanced progesterone signaling was determined to not occur due to post-translational phosphorylation or by reducing progesterone receptor (PR) protein levels but instead increased PR protein levels in T47D breast cancer cells, which could be blocked by estrogen receptor (ER) antagonists, suggesting an ER dependent effect. "
2.	Endometrial Neoplasms (Endometrial Cancer) 12/24/2021 - "A siRNA knockdown of GR in Ishikawa PR-B endometrial cancer cells reduced irilone's ability to enhance progesterone signaling. "
3.	Ovarian Neoplasms (Ovarian Cancer) 01/01/2018 - "We found that the component irilone (1) potentiated the effect of progesterone in both endometrial and ovarian cancer cell lines. "

Related Drugs and Biologics

1.	Progesterone
2.	Progesterone Receptors (Progesterone Receptor)
3.	Estrogen Receptors
4.	Proteins (Proteins, Gene)
5.	Small Interfering RNA (siRNA)