3- ((5- (6- methylpyridin- 2- yl)- 4- (quinoxalin- 6- yl)- 1H- imidazol- 2- yl)methyl)benzamide

10/01/2006 - "We evaluated the efficacy of IN-1130 to block renal fibrogenesis induced by unilateral ureteral obstruction (UUO) in rats. "

11/01/2017 - "Therapeutic efficacy was assessed in 1130 patients with a standard evaluation for leg pain. "

08/28/2014 - "Additionally, we demonstrated that IN-1130 blocked TGF-β-induced 4T1 mammary cancer cell migration and invasion. "
08/28/2014 - "In summary, this study indicated that IN-1130 has therapeutic potential for preventing breast cancer metastasis to the lung. "
08/28/2014 - "An novel inhibitor of TGF-β type I receptor, IN-1130, blocks breast cancer lung metastasis through inhibition of epithelial-mesenchymal transition."
03/01/2008 - "The authors investigated the pharmacokinetics and metabolism of 3-((5-(6-methylpyridin-2-yl)-4-(quinoxalin-6-yl)-1H-imidazol-2-yl)methyl)benzamide (IN-1130), a novel ALK5 inhibitor, which suppresses renal and hepatic fibrosis, and also exerts anti-metastatic effects on breast cancer-bearing MMTV-cNeu mice model. "
08/28/2014 - "Furthermore, we found that lung metastasis from primary breast cancer was inhibited by IN-1130 in both 4T1-xenografted BALB/c mice and MMTV/c-Neu transgenic mice without any change in primary tumor volume. "

01/09/2020 - "We performed a genome-wide association study (GWAS) of opioid cessation (defined as abstinence from illicit opioids for >1 year or <6 months before the interview date) in 1130 African American (AA) and 2919 European ancestry (EA) participants recruited for genetic studies of substance use disorders and who met lifetime Diagnostic and Statistical Manual of Mental Disorders, 5th Edition (DSM-5) criteria for OUD. "

08/28/2014 - "In summary, this study indicated that IN-1130 has therapeutic potential for preventing breast cancer metastasis to the lung. "
08/28/2014 - "Here, we show that IN-1130 suppressed EMT and the lung metastasis of mammary tumors in mouse models. "
08/28/2014 - "An novel inhibitor of TGF-β type I receptor, IN-1130, blocks breast cancer lung metastasis through inhibition of epithelial-mesenchymal transition."
08/28/2014 - "Furthermore, we found that lung metastasis from primary breast cancer was inhibited by IN-1130 in both 4T1-xenografted BALB/c mice and MMTV/c-Neu transgenic mice without any change in primary tumor volume. "