|1.||McPhail, Kerry L: 3 articles (03/2015 - 01/2013)|
|2.||Ishmael, Jane E: 3 articles (03/2015 - 01/2013)|
|3.||Serrill, Jeffrey D: 2 articles (03/2015 - 01/2013)|
|4.||Proteau, Philip J: 2 articles (03/2015 - 01/2013)|
|5.||Hau, Andrew M: 2 articles (01/2015 - 01/2013)|
|6.||Gerwick, William H: 1 article (03/2015)|
|7.||Medina, Rebecca A: 1 article (03/2015)|
|8.||Li, Dong: 1 article (03/2015)|
|9.||Videau, Patrick: 1 article (03/2015)|
|10.||Mitchell, Edward A: 1 article (03/2015)|
01/01/2013 - "Coibamide A represents a natural product scaffold with potential for the study of mTOR-independent signaling and cell death mechanisms in apoptotic-resistant cancer cells."
01/15/2015 - "The macrocyclization of the resulting linear peptide provided the [d-MeAla(11)]-epimer of coibamide A, which exhibited nanomolar cytotoxic activity towards a number of human cancer cell lines. "
01/01/2013 - "Previous testing of coibamide A in the NCI in vitro 60 cancer cell line panel revealed a potent anti-proliferative response and "COMPARE-negative" profile indicative of a unique mechanism of action. "
03/27/2015 - "Two new cyclic depsipeptides, companeramides A (1) and B (2), have been isolated from the phylogenetically characterized cyanobacterial collection that yielded the previously reported cancer cell toxin coibamide A (collected from Coiba Island, Panama). "
|2.||Glioblastoma (Glioblastoma Multiforme)
01/01/2013 - "We report that coibamide A is a more potent and efficacious cytotoxin than was previously appreciated, inducing concentration- and time-dependent cytotoxicity (EC50<100 nM) in human U87-MG and SF-295 glioblastoma cells and mouse embryonic fibroblasts (MEFs). "
01/01/2013 - "Coibamide A induces mTOR-independent autophagy and cell death in human glioblastoma cells."
01/01/2013 - "We show that coibamide A induces autophagosome accumulation in human glioblastoma cell types and MEFs via an mTOR-independent mechanism; no change was observed in the phosphorylation state of ULK1 (Ser-757), p70 S6K1 (Thr-389), S6 ribosomal protein (Ser-235/236) and 4EBP-1 (Thr-37/46). "
|2.||Ribosomal Proteins (Ribosomal Protein)
|3.||2,5-dichloro-4-bromophenol (B 2)