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locostatin

an RKIP inhibitor that reduces cell migration

Networked: 9 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Oxazoles: 89
      - Oxazolidinones: 316
        locostatin: 9

Experts

1.	Bai, Facheng: 2 articles (10/2018 - 01/2017)
2.	Huang, Quanfang: 2 articles (10/2018 - 01/2017)
3.	Lin, Xing: 2 articles (10/2018 - 01/2017)
4.	Nie, Jinlan: 2 articles (10/2018 - 01/2017)
5.	Zhu, Xunshuai: 2 articles (10/2018 - 01/2017)
6.	Zhuo, Lang: 2 articles (10/2018 - 01/2017)
7.	Ciarmela, Pasquapina: 2 articles (11/2016 - 05/2012)
8.	Islam, Md Soriful: 2 articles (11/2016 - 05/2012)
9.	Petraglia, Felice: 2 articles (11/2016 - 05/2012)
10.	Gu, Lingui: 1 article (01/2022)

Related Diseases

1.	Acute Liver Failure (Fulminant Hepatic Failure) 10/01/2018 - "In the present study, acute liver failure was induced by thioacetamide in mice, and locostatin was used to interfere with RKIP expression. "
2.	Liver Cirrhosis (Hepatic Cirrhosis) 01/01/2019 - "In this study, we investigated the effect of locostatin on liver fibrosis and its underlying mechanism. " 01/01/2019 - "Locostatin mitigated liver fibrosis and inflammation induced by CCl4. " 01/01/2019 - "Carbon tetrachloride (CCl4) was used to induce liver fibrosis in mice, and locostatin was injected intraperitoneally. " 01/01/2019 - "Locostatin Alleviates Liver Fibrosis Induced by Carbon Tetrachloride in Mice."
3.	Inflammation (Inflammations) 01/01/2019 - "Locostatin mitigated liver fibrosis and inflammation induced by CCl4. " 01/01/2017 - "Interestingly, OVD notably enhanced Raf kinase inhibitor protein (RKIP) expression, and the effects of OVD on histological changes, oxidative stress and inflammation was largely abolished by the RKIP specific inhibitor locostatin. " 12/01/2009 - "Therefore, locostatin should be a useful therapeutic to control inflammation, sepsis, and autoimmune diseases."
4.	Sepsis (Septicemia) 12/01/2009 - "Therefore, locostatin should be a useful therapeutic to control inflammation, sepsis, and autoimmune diseases."
5.	B-Cell Chronic Lymphocytic Leukemia (Chronic Lymphocytic Leukemia) 12/01/2018 - "Inhibition of the Raf-1 kinase inhibitory protein (RKIP) by locostatin induces cell death and reduces the CXCR4-mediated migration of chronic lymphocytic leukemia cells."

Related Drugs and Biologics

1.	Thioacetamide (Thioacetamid)
2.	Phosphatidylethanolamine Binding Protein
3.	Mitogen-Activated Protein Kinase Kinases (MEKs)
4.	Proto-Oncogene Proteins c-raf
5.	Proteins (Proteins, Gene)
6.	Ovalbumin
7.	Carbon Tetrachloride (Tetrachloromethane)
8.	didymin
9.	belnacasan