peptidimer-c

a synthetic peptide in which a peptide dimer is linked to penetratin; binds two SH3 domains of Grb2; putative antineoplastic agent; amino acid sequence in first source

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Assayag, Franck: 1 article (07/2007)
2.	Garbay, Christiane: 1 article (07/2007)
3.	Gril, Brunilde: 1 article (07/2007)
4.	Liu, Wang-Qing: 1 article (07/2007)
5.	Poupon, Marie-France: 1 article (07/2007)
6.	Vidal, Michel: 1 article (07/2007)

Related Diseases

1.	Neoplasms (Cancer) 07/15/2007 - "Combined treatment of peptidimer-c with docetaxel further inhibited both colony formation and tumor cell survival compared to docetaxel treatment alone. " 07/15/2007 - "A specific Grb2-SH3 ligand, designed and synthesized in our laboratory, called peptidimer-c, inhibited colony formation in HER2 overexpressing SKBr3 cancer cells. "
2.	Breast Neoplasms (Breast Cancer) 07/15/2007 - "Finally, peptidimer-c reduced the growth of a HER2(+) human breast cancer (BK111) xenograft in nude mice and potentiated the antitumor effect of docetaxel in a HER2+ hormone-independent human prostate adenocarcinoma (PAC120 HID28) xenograft. "
3.	Adenocarcinoma 07/15/2007 - "Finally, peptidimer-c reduced the growth of a HER2(+) human breast cancer (BK111) xenograft in nude mice and potentiated the antitumor effect of docetaxel in a HER2+ hormone-independent human prostate adenocarcinoma (PAC120 HID28) xenograft. "

Related Drugs and Biologics

1.	Ligands
2.	Hormones (Hormone)
3.	Docetaxel (Taxotere)