KR-31762

KATP channel opener that exerts cardioprotective effects by opening SarcKATP channels in rat models of ischemia/reperfusion-induced heart injury; structure in first source

Also Known As:

1-((2R,3S,4R)-3.4-dihydro-2-dimethoxymethyl-3-hydroxy-2-methyl-6-nitro-2H-1-benzopyran-4-yl)-(2R)-5-methoxy-2,3-dihydro-1H-indole-2-carboxylic acid ethyl ester

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrans: 130
    - Benzopyrans: 195
      - KR-31762: 1
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Indoles: 200
      - KR-31762: 1
    - Benzopyrans: 195
      - KR-31762: 1

Experts

1.	Choi, Wahn-Soo: 1 article (04/2008)
2.	Lee, Byung-Ho: 1 article (04/2008)
3.	Lee, Chang-Soo: 1 article (04/2008)
4.	Lee, Sung-Hun: 1 article (04/2008)
5.	Lim, Jong-Hyun: 1 article (04/2008)
6.	Seo, Ho-Won: 1 article (04/2008)
7.	Shin, Hwa-Sup: 1 article (04/2008)
8.	Won, Hyung-Sik: 1 article (04/2008)
9.	Yang, Min-Kyu: 1 article (04/2008)
10.	Yi, Kyu-Yang: 1 article (04/2008)

Related Diseases

1.	Ischemia 04/01/2008 - "In isolated rat hearts subjected to 30-min global ischemia followed by 30-min reperfusion, KR-31762 (3 and 10 microM) significantly increased the left ventricular developed pressure (LVDP) and double product (heart rate x LVDP) after 30-min reperfusion in a concentration-dependent manner, while decreasing the left ventricular end-diastolic pressure (LVEDP). " 04/01/2008 - "The cardioprotective effects of KR-31762, a newly synthesized K+(ATP) opener, were evaluated in rat models of ischemia/reperfusion (I/R) heart injury. " 04/01/2008 - "KR-31762, a novel KATP channel opener, exerts cardioprotective effects by opening SarcKATP channels in rat models of ischemia/reperfusion-induced heart injury."
2.	Infarction (Infarctions) 04/01/2008 - "In anesthetized rats subjected to 45-min occlusion of left anterior descending coronary artery followed by 90-min reperfusion, KR-31762 significantly decreased the infarct size (60.8, 40.5 and 37.8% for control, 0.3 and 1.0 mg/kg, iv, respectively). "
3.	Heart Injuries 04/01/2008 - "The cardioprotective effects of KR-31762, a newly synthesized K+(ATP) opener, were evaluated in rat models of ischemia/reperfusion (I/R) heart injury. " 04/01/2008 - "KR-31762, a novel KATP channel opener, exerts cardioprotective effects by opening SarcKATP channels in rat models of ischemia/reperfusion-induced heart injury."
4.	Contracture 04/01/2008 - "KR-31762 also significantly increased the time to contracture (TTC) during ischemic period (20.0, 22.4 and 26.4 min for control, 3 and 10 microM, respectively), while decreasing the release of lactate dehydrogenase (LDH) from the heart during 30 min reperfusion (30.4, 14.3 and 19.7 U/g heart weight, respectively). "

Related Drugs and Biologics

1.	KATP Channels
2.	L-Lactate Dehydrogenase (Lactate Dehydrogenase)
3.	Adenosine Triphosphate (ATP)