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2,2- difluorobenzo(1,3)dioxole- 5- carboxylic acid indan-2-ylamide

an antiatherosclerotic agent that enhances eNOS promoter activity

Also Known As:

AVE 3085; AVE-3085; AVE3085

Networked: 5 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Wohlfart, Paulus: 3 articles (10/2014 - 05/2008)
2.	Ruetten, Hartmut: 2 articles (10/2014 - 05/2008)
3.	He, Guo-Wei: 2 articles (07/2011 - 07/2010)
4.	Li, Huige: 2 articles (07/2011 - 05/2008)
5.	Xue, Hong-Mei: 2 articles (07/2011 - 07/2010)
6.	Yang, Qin: 2 articles (07/2011 - 07/2010)
7.	Colby, Amy: 1 article (10/2014)
8.	Huang, Yuh-Chin T: 1 article (10/2014)
9.	Jozefowski, Szczepan: 1 article (10/2014)
10.	Kahlert, Johnny A: 1 article (10/2014)

Related Diseases

1.	Pneumonia (Pneumonitis) 10/15/2014 - "Pharmacologic targeting of NOS3 with statins or another small-molecule compound (AVE3085) enhanced macrophage bacterial killing, improved bacterial clearance, and increased host survival in both primary and secondary (post-influenza) pneumonia. "
2.	Human Influenza (Influenza) 10/15/2014 - "Pharmacologic targeting of NOS3 with statins or another small-molecule compound (AVE3085) enhanced macrophage bacterial killing, improved bacterial clearance, and increased host survival in both primary and secondary (post-influenza) pneumonia. "
3.	Hypertension (High Blood Pressure) 07/01/2011 - "The present study investigated the effects of AVE3085 in endothelial dysfunction associated with hypertension. "
4.	Atherosclerotic Plaque (Atheroma) 05/01/2008 - "A 12-week treatment with AVE9488 or AVE3085 reduced atherosclerotic plaque formation in apoE-KO mice, but not in apoE/eNOS-double knockout mice. "
5.	Inflammation (Inflammations) 12/01/2008 - "In a rat model of severe diabetes, pharmacological enhancement of impaired eNOS production and NO-cGMP signalling by AVE3085 restores altered hindlimb blood flow and prevents vascular inflammation."

Related Drugs and Biologics

1.	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)
2.	Solutions
3.	Arginine (L-Arginine)
4.	Apolipoproteins E (ApoE)
5.	4-fluoro-N-indan-2-yl-benzamide